Siegfried J, Wieser H G
Neurochirurgie. 1978;24(6):407-14.
There is some evidence that stimulation of the periaqueductal gray matter produced analgesia is accomplished by the activation of neuronal systems where endorphins are thought to be transmittors. However, the neurophysiological mechanism of this stimulation is not elucided. In this preliminary paper, the spontaneous and the evoked electrical activity has been studied in 3 patients operated on with implantation of an electrode in the periaqueductal gray matter for chronic pain. Particularly interesting are the pronounced decrease of the evoked potentials in the sensory nucleus of the thalamus after stimulation of the periaqueductal gray matter.
有证据表明，刺激导水管周围灰质产生镇痛作用是通过激活内啡肽被认为是递质的神经元系统来实现的。然而，这种刺激的神经生理机制尚未阐明。在这篇初步论文中，对3例因慢性疼痛在导水管周围灰质植入电极进行手术的患者的自发和诱发电活动进行了研究。特别有趣的是，刺激导水管周围灰质后，丘脑感觉核中诱发电位明显降低。
