原发性干燥综合征中的心血管疾病
Cardiovascular Disease in Primary Sjögren's Syndrome.
作者信息
Berardicurti Onorina, Ruscitti Piero, Cipriani Paola, Ciccia Francesco, Liakouli Vasiliki, Guggino Giuliana, Carubbi Francesco, Di Benedetto Paola, Triolo Giovanni, Giacomelli Roberto
机构信息
Division of Rheumatology, University of L`Aquila, L`Aquila, Italy.
Division of Rheumatology, University of Palermo, Palermo, Italy.
出版信息
Rev Recent Clin Trials. 2018;13(3):164-169. doi: 10.2174/1574887113666180315130336.
BACKGROUND
A close relationship between rheumatic diseases and cardiovascular disease (CVD) has been reported, accounting for the higher mortality and morbidity observed in these patients. In the last years, it has been clearly reported that patients affected by primary Sjögren's syndrome (pSS) experienced an increased risk of CVD.
OBJECTIVE
This review aimed at investigating CVD, traditional cardiovascular (CV) risk factors and possible targeted therapeutic strategies in pSS patients.
METHOD
Available literature concerning CV risk factors in pSS patients has been selected and discussed.
CONCLUSION
Disease-related characteristics and traditional CV risk factors contribute to observed atherosclerotic damage in pSS patients. The pro-inflammatory mediators together with hypertension and type 2 diabetes, which are more prevalent in pSS patients, determine the increased CV burden. Future studies are needed to fully elucidate the role of possible targeted therapies.
背景
已有报道称风湿性疾病与心血管疾病（CVD）之间存在密切关系，这也是这些患者死亡率和发病率较高的原因。近年来，已有明确报道称原发性干燥综合征（pSS）患者发生CVD的风险增加。
目的
本综述旨在研究pSS患者的CVD、传统心血管（CV）危险因素及可能的靶向治疗策略。
方法
选取并讨论了有关pSS患者CV危险因素的现有文献。
结论
疾病相关特征和传统CV危险因素导致了pSS患者出现动脉粥样硬化损伤。促炎介质与pSS患者中更常见的高血压和2型糖尿病共同导致了CV负担的增加。需要进一步的研究来充分阐明可能的靶向治疗的作用。
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