Pérez Paulina A Santander, Ceschin Álvaro P, Moraes Daniela M P de, Oliveira Lucileine K S N de, Ceschin Nathan I, Ichikawa Nathan
Feliccità Instituto de Fertilidade, Curitiba, Brazil.
JBRA Assist Reprod. 2018 Jun 1;22(2):95-98. doi: 10.5935/1518-0557.20180008.
To analyze progesterone and prolactin plasma levels nine days after oocyte retrieval and evaluate their correlation with pregnancy rates in in vitro fertilization cycles. To achieve pregnancy, several factors are analyzed before and during the in vitro fertilization cycle. Progesterone supplementation for adequate luteal phase support is indicated despite the presence of multiple corpus luteum in IVF stimulation cycles because of blockage caused by hypothalamic agonists and antagonists. The dosage of progesterone and prolactin on day 09 after follicular retrieval could function as a predictive marker of success in fertility treatments.
A retrospective study was performed using data from 238 patients submitted to intracytoplasmic sperm injection (ICSI) at a private infertility clinic from January 2013 to December 2015. Hormonal measurements were performed on day 09 after follicular uptake. The data was compared to assess the correlation between prolactin and progesterone dosages and pregnancy rates.
The ICSI pregnancy rate was 40.8% (n=238). No statistically significant difference was observed when correlating the success of the procedure with the prolactin dosage (p=0.71). However, progesterone showed a significant difference (p=0.021). The cutoff point, indicated by the ROC curve fit according to which gestation would be identified, is 25.95ng/ml of progesterone. The sensitivity of this point is 61.9% and the specificity is 57.4%.
Progesterone dosage may be one of the indicators of gestation on day 09 after follicular uptake. Such data can help physicians to monitoring and provides suitable early gestational care. More studies are needed to corroborate the data found.
分析取卵后九天的血浆孕酮和催乳素水平，并评估它们与体外受精周期妊娠率的相关性。为实现妊娠，在体外受精周期前后会分析多个因素。尽管在体外受精刺激周期中存在多个黄体，但由于下丘脑激动剂和拮抗剂造成的阻滞，仍需补充孕酮以提供足够的黄体期支持。取卵后第9天的孕酮和催乳素剂量可作为生育治疗成功的预测指标。
进行一项回顾性研究，使用2013年1月至2015年12月在一家私立不孕诊所接受卵胞浆内单精子注射（ICSI）的238例患者的数据。在取卵后第9天进行激素测量。比较数据以评估催乳素和孕酮剂量与妊娠率之间的相关性。
ICSI妊娠率为40.8%（n = 238）。将手术成功率与催乳素剂量相关联时，未观察到统计学上的显著差异（p = 0.71）。然而，孕酮显示出显著差异（p = 0.021）。根据ROC曲线拟合确定的妊娠识别临界值为孕酮25.95ng/ml。该点的敏感性为61.9%，特异性为57.4%。
取卵后第9天的孕酮剂量可能是妊娠的指标之一。这些数据可帮助医生进行监测并提供适当的早期妊娠护理。需要更多研究来证实所发现的数据。
