Neuropharmacology Research Laboratory, Jeffrey Cheah School of Medicine and Health Sciences, Monash University Malaysia, Bandar Sunway, 47500 Subang Jaya, Selangor, Malaysia.
Int J Mol Sci. 2018 Mar 15;19(3):871. doi: 10.3390/ijms19030871.
Metabolic epilepsy is a metabolic abnormality which is associated with an increased risk of epilepsy development in affected individuals. Commonly used antiepileptic drugs are typically ineffective against metabolic epilepsy as they do not address its root cause. Presently, there is no review available which summarizes all the treatment options for metabolic epilepsy. Thus, we systematically reviewed literature which reported on the treatment, therapy and management of metabolic epilepsy from four databases, namely PubMed, Springer, Scopus and ScienceDirect. After applying our inclusion and exclusion criteria as per the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines, we reviewed a total of 43 articles. Based on the reviewed articles, we summarized the methods used for the treatment, therapy and management of metabolic epilepsy. These methods were tailored to address the root causes of the metabolic disturbances rather than targeting the epilepsy phenotype alone. Diet modification and dietary supplementation, alone or in combination with antiepileptic drugs, are used in tackling the different types of metabolic epilepsy. Identification, treatment, therapy and management of the underlying metabolic derangements can improve behavior, cognitive function and reduce seizure frequency and/or severity in patients.
代谢性癫痫是一种代谢异常，与个体癫痫发作风险增加有关。常用的抗癫痫药物通常对代谢性癫痫无效，因为它们没有解决其根本原因。目前，尚无综述总结代谢性癫痫的所有治疗选择。因此，我们系统地回顾了来自 PubMed、Springer、Scopus 和 ScienceDirect 这四个数据库中关于代谢性癫痫治疗、疗法和管理的文献。根据系统评价和荟萃分析的首选报告项目（PRISMA）指南的纳入和排除标准，我们共回顾了 43 篇文章。根据综述的文章，我们总结了代谢性癫痫治疗、疗法和管理的方法。这些方法是针对代谢紊乱的根本原因量身定制的，而不仅仅是针对癫痫表型。饮食调整和饮食补充，单独或与抗癫痫药物联合使用，用于治疗不同类型的代谢性癫痫。识别、治疗、治疗和管理潜在的代谢紊乱可以改善患者的行为、认知功能，并减少癫痫发作的频率和/或严重程度。
