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基于访谈的营养不良评估可预测初次和翻修关节置换术后6个月内的不良事件——一项对351例患者的前瞻性观察研究。

Interview based malnutrition assessment can predict adverse events within 6 months after primary and revision arthroplasty - a prospective observational study of 351 patients.

作者信息

Ihle Christoph, Weiß Christoph, Blumenstock Gunnar, Stöckle Ulrich, Ochs Björn Gunnar, Bahrs Christian, Nüssler Andreas, Schreiner Anna Janine

机构信息

Siegfried Weller Institute for Trauma Research, BG Trauma Center Tübingen, Eberhard Karls University Tübingen, Schnarrenbergstrasse 95, 72076, Tübingen, Germany.

Department of Clinical Epidemiology and Applied Biometry, Eberhard Karls University Tübingen, Silcherstrasse 5, 72076, Tubingen, Germany.

出版信息

BMC Musculoskelet Disord. 2018 Mar 15;19(1):83. doi: 10.1186/s12891-018-2004-z.

Abstract

BACKGROUND

Being at risk for malnutrition can be observed among hospitalized patients of all medical specialties. There are only few studies in arthroplasty dealing with defining and assessing malnutrition as such a potentially risk. This study aims to identify the risk for malnutrition following primary (pAP) and revision arthroplasty (rAP) (1) using non-invasive interview based assessment tools and to analyze effects on clinical outcome (2) and quality of life (3).

METHODS

A consecutive series of hospitalized patients of a Department of Arthroplasty at a Level 1 Trauma Center in Western Europe was observed between June 2014 and June 2016. Patients were monitored for being at risk for malnutrition at hospital admission (T1) and 6 months post surgery (T2) by non-invasive interview based assessment tools (NRS 2002, SF-MNA, MNA). Adverse events, length of hospital stay and quality of life (HRQL, SF-36) were monitored.

RESULTS

351 (283 pAP/ 68 rAP) patients were included. At T1, 13.4% (47) / 23.9% (84) / 27.4% (96) and at T2 7.3% (18) / 17.1% (42) / 16.0% (39) of all patients were at risk for malnutrition regarding NRS/SF-MNA/MNA. Prevalence of malnutrition risk was higher in rAP (22.1-29.4%) compared to pAP (11.3-26.9%). Patients being at risk for malnutrition showed prolonged hospitalization (NRS 14.5 to 12.5, SF-MNA 13.7 to 12.4, MNA 13.9 to 12.3 days, p < 0.05), delayed mobilization (NRS 2.1 to 1.7, SF-MNA 1.8 to 1.7, MNA 1.9 to 1.7 days), lower values in HRQL and more adverse events.

CONCLUSIONS

There is a moderate to high prevalence of risk for malnutrition in arthroplasty that can easily be assessed through interview based screening tools. Being at risk for malnutrition can reduce the clinical outcome following pAP and rAP. Patients with an impaired nutritional status show reduced values in physical and mental aspects of HRQL. Non-invasive interview-based nutritional assessment can predict adverse events in primary and revision total arthroplasty and can therefore help identifying patients at risk before surgery.

TRIAL REGISTRATION

The study protocol was approved by the local ethics committee (193/2014BO2) and registered at the German Clinical Trials Register according to WHO standard ( DKRS00006192 ).

摘要

背景

所有医学专科的住院患者中都可能存在营养不良风险。在关节置换领域,针对将营养不良定义并评估为潜在风险的研究较少。本研究旨在(1)使用基于非侵入性访谈的评估工具,确定初次关节置换术(pAP)和翻修关节置换术(rAP)后发生营养不良的风险,并分析其对(2)临床结局和(3)生活质量的影响。

方法

2014年6月至2016年6月期间,对西欧一家一级创伤中心关节置换科的一系列连续住院患者进行观察。通过基于非侵入性访谈的评估工具(NRS 2002、SF-MNA、MNA),在患者入院时(T1)和术后6个月(T2)监测其营养不良风险。监测不良事件、住院时间和生活质量(HRQL,SF-36)。

结果

共纳入351例患者(283例pAP/68例rAP)。在T1时,根据NRS/SF-MNA/MNA,所有患者中分别有13.4%(47例)/23.9%(84例)/27.4%(96例)存在营养不良风险;在T2时,分别有7.3%(18例)/17.1%(42例)/16.0%(39例)。翻修关节置换术(rAP)患者的营养不良风险患病率(22.1-29.4%)高于初次关节置换术(pAP)患者(11.3-26.9%)。存在营养不良风险的患者住院时间延长(NRS从14.5天延长至12.5天,SF-MNA从13.7天延长至12.4天,MNA从13.9天延长至12.3天,p<0.05),活动延迟(NRS从2.1天延迟至1.7天,SF-MNA从1.8天延迟至1.7天,MNA从1.9天延迟至1.7天),HRQL值较低,不良事件更多。

结论

关节置换术中营养不良风险的患病率为中度至高度,可通过基于访谈的筛查工具轻松评估。营养不良风险会降低初次关节置换术(pAP)和翻修关节置换术(rAP)后的临床结局。营养状况受损的患者在HRQL的身体和心理方面得分较低。基于非侵入性访谈的营养评估可预测初次和翻修全关节置换术中的不良事件,因此有助于在手术前识别有风险的患者。

试验注册

本研究方案已获当地伦理委员会批准(193/2014BO2),并根据世界卫生组织标准在德国临床试验注册中心注册(DKRS00006192)。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8677/5856317/2f322c6374b0/12891_2018_2004_Fig1_HTML.jpg

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