胰腺癌中淋巴细胞与单核细胞比值：预后意义及荟萃分析。
Lymphocyte-to-monocyte ratio in pancreatic cancer: Prognostic significance and meta-analysis.
机构信息
Department of Breast surgery, Thyroid surgery, Pancreatic surgery, Huangshi Central Hospital of Edong Healthcare Group, Hubei Polytechnic University, No.141, Tianjin Road, Huangshi, Hubei, China.
Department of Breast surgery, Thyroid surgery, Pancreatic surgery, Huangshi Central Hospital of Edong Healthcare Group, Hubei Polytechnic University, No.141, Tianjin Road, Huangshi, Hubei, China.
出版信息
Clin Chim Acta. 2018 Jun;481:142-146. doi: 10.1016/j.cca.2018.03.008. Epub 2018 Mar 12.
BACKGROUND
An increasing number of studies have investigated the prognostic value of the lymphocyte-to-monocyte ratio (LMR) in various types of cancer. The present meta-analysis was designed to investigate its prognostic value of pretreatment LMR in pancreatic cancer (PC).
METHODS
An integrated meta-analysis was conducted and eligible studies were recruited by a systematic search in MEDLINE, EMBASE, and Cochrane databases. The association between LMR and survival outcomes and clinicopathological features were analyzed in PC patients.
RESULTS
A total of 10 studies (11 cohorts) comprising 2557 patients were included in this meta-analysis. The result demonstrated that low LMR could predict unfavorable overall survival(OS) (HR: 0.60, 95% confidence interval [CI]: 0.50-0.71, p < 0.001) and disease-free survival (DFS)/recurrence-free survival (RFS) (HR: 0.43, 95% CI: 0.20-0.94, p = 0.03). Moreover, low LMR was also positively correlated with male patients, CA199, and TNM stage.
CONCLUSIONS
This study suggested that low pretreatment LMR was associated with advanced clinicopathological features and poor prognosis as a predicative factor in patients with PC.
背景
越来越多的研究探讨了淋巴细胞与单核细胞比值（LMR）在各种癌症类型中的预后价值。本荟萃分析旨在探讨其在胰腺癌（PC）患者中的预后价值。
方法
通过系统检索 MEDLINE、EMBASE 和 Cochrane 数据库，进行综合荟萃分析并纳入合格研究。分析 LMR 与 PC 患者生存结局和临床病理特征之间的关系。
结果
本荟萃分析共纳入 10 项研究（11 个队列），共计 2557 例患者。结果表明，低 LMR 可预测总生存期（OS）不良（HR：0.60，95%置信区间[CI]：0.50-0.71，p<0.001）和无病生存期（DFS）/无复发生存期（RFS）（HR：0.43，95%CI：0.20-0.94，p=0.03）。此外，低 LMR 还与男性患者、CA199 和 TNM 分期呈正相关。
结论
本研究表明，低术前 LMR 与晚期临床病理特征和不良预后相关，是 PC 患者的一种预测因子。
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