Kwiatkowska-Patzer B, Zalewska T
Basic Res Cardiol. 1987 Jan-Feb;82(1):18-23. doi: 10.1007/BF01907049.
The aim of the study was to investigate the effect of propranolol upon the activity of proteases in rat myocardium subjected to aortic stenosis. In acute heart hypertrophy induced by aortic stenosis, the activity of all three proteases in the myocardium does not change significantly. Propranolol in the concentration of 10(-6) to 2 X 10(-4) M inhibited proteolytic activity dependent on neutral proteases. The degree of inhibition increased simultaneously with increasing concentrations of propranolol. Propranolol in a low concentration (10(-6)-10(-5) M) also inhibited proteolytic activity dependent on alkaline and acidic proteases, but in higher concentration (10(-4)-2 X 10(-4) M) stimulated proteolytic activity of these enzymes 2-3 times.
本研究的目的是探讨普萘洛尔对主动脉狭窄大鼠心肌中蛋白酶活性的影响。在主动脉狭窄诱导的急性心脏肥大中，心肌中所有三种蛋白酶的活性均无显著变化。浓度为10(-6)至2×10(-4)M的普萘洛尔抑制了依赖于中性蛋白酶的蛋白水解活性。抑制程度随普萘洛尔浓度的增加而同时增加。低浓度（10(-6)-10(-5)M）的普萘洛尔也抑制了依赖于碱性和酸性蛋白酶的蛋白水解活性，但在高浓度（10(-4)-2×10(-4)M）下，这些酶的蛋白水解活性被刺激了2-3倍。
