特发性充血性心肌病患者的抑制性T淋巴细胞功能
Suppressor T lymphocyte function in patients with idiopathic congestive cardiomyopathy.
作者信息
Lowry P J, Gammage M D, Gentle T A, Baynham M I, Thompson R A, Littler W A
出版信息
Br Heart J. 1987 May;57(5):458-61. doi: 10.1136/hrt.57.5.458.
Suppressor T lymphocyte function was examined in 11 patients with idiopathic congestive cardiomyopathy and in 11 age and sex matched patients with a similar degree of heart failure resulting from ischaemic heart disease. Suppressor T lymphocyte function was also assessed in a control population of 11 normal subjects. Suppressor T lymphocyte function was reduced in both groups of patients with heart failure but not significantly, and a wide range of suppression was demonstrated in all groups. These data do not support the hypothesis that there is a defect in T lymphocyte function in patients with congestive cardiomyopathy, but they do suggest that there may be a non-specific reduction in T lymphocyte suppressor function associated with heart failure in general.
对11例特发性充血性心肌病患者以及11例年龄和性别相匹配、因缺血性心脏病导致心力衰竭程度相似的患者进行了抑制性T淋巴细胞功能检测。还对11名正常受试者的对照人群进行了抑制性T淋巴细胞功能评估。两组心力衰竭患者的抑制性T淋巴细胞功能均降低，但不显著，且所有组均表现出广泛的抑制作用。这些数据不支持充血性心肌病患者存在T淋巴细胞功能缺陷的假设，但确实表明，一般而言，心力衰竭可能与T淋巴细胞抑制功能的非特异性降低有关。
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