具有心脏活性的DPI 201-106对钠泵的抑制作用。
Inhibition of the sodium pump by cardioactive DPI 201-106.
作者信息
Kaumann A J, Richards D E, Russell D A
出版信息
Br J Pharmacol. 1987 May;91(1):3-5. doi: 10.1111/j.1476-5381.1987.tb08975.x.
Abstract
The effects of DPI 201-106 were examined on contractions of papillary muscles from the right ventricle of feline heart, on [3H]-ouabain binding and Na+, K+-ATPase activity in feline ventricular membrane particles and on ouabain-sensitive 86Rb uptake in human erythrocytes. DPI 201-106 partially inhibited the Na+ pump at concentrations that caused pronounced positive inotropic effects.
摘要
研究了DPI 201 - 106对猫右心室乳头肌收缩、猫心室膜颗粒中[³H] - 哇巴因结合及钠钾ATP酶活性以及对人红细胞中哇巴因敏感的⁸⁶Rb摄取的影响。DPI 201 - 106在产生明显正性肌力作用的浓度下部分抑制钠泵。
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