Department of Inorganic and Organic Chemistry, University of Barcelona, Martí i Franquès 1-11, 08028 Barcelona, Spain.
Faculty of Chemistry and Chemical Technology, University of Ljubljana, Večna pot 113, SI-1000 Ljubljana, Slovenia.
Dalton Trans. 2018 Apr 3;47(14):4902-4908. doi: 10.1039/C7DT04604A.
The [Cu(L)Cl2]2 and [Pt(L)Cl2] complexes were prepared from the simple Schiff-base ligand (E)-phenyl-N-((pyridin-2-yl)methylene)methanamine (L) and respectively, CuCl2 and cis-[PtCl2(DMSO)2]. DNA-interaction studies revealed that the copper complex most likely acts as a DNA cleaver whereas the platinum complex binds to the double helix. Remarkably, cell-viability experiments with HeLa, MCF7 and PC3 cells showed that [Cu(L)Cl2]2 is an efficient cytotoxic agent whereas [Pt(L)Cl2] is not toxic, illustrating the crucial role played by the nature of the metal ion in the corresponding biological activity.
[Cu(L)Cl2]2 和 [Pt(L)Cl2] 配合物由简单的席夫碱配体 (E)-苯亚甲基-N-((吡啶-2-基)亚甲基)甲胺 (L) 和分别的 CuCl2 和 cis-[PtCl2(DMSO)2] 制备。DNA 相互作用研究表明，铜配合物很可能作为 DNA 切割剂，而铂配合物结合到双螺旋结构中。值得注意的是，用 HeLa、MCF7 和 PC3 细胞进行的细胞活力实验表明，[Cu(L)Cl2]2 是一种有效的细胞毒性剂，而 [Pt(L)Cl2] 没有毒性，这说明了金属离子的性质在相应的生物活性中起着关键作用。
