铑(III)催化的异氰酸酯与 C(sp)-H 键的氨甲酰化反应。
Rhodium(III)-Catalyzed C(sp)-H Bond Aminocarbonylation with Isocyanates.
机构信息
Key Laboratory of Interfacial Reaction & Sensing Analysis in Universities of Shandong, School of Chemistry and Chemical Engineering , University of Jinan , Jinan , Shandong , 250022 , P. R. China.
Shandong Provincial Key Laboratory of Fluorine Chemistry and Chemical Materials, School of Chemistry and Chemical Engineering , University of Jinan , Jinan 250022 , P. R. China.
出版信息
J Org Chem. 2018 Apr 6;83(7):4153-4159. doi: 10.1021/acs.joc.8b00086. Epub 2018 Mar 21.
Rh(III)-catalyzed C(sp)-H bond aminocarbonylation of 8-methylquinolines and isocyanates has been realized under mild conditions. This approach is applicable to different aryl and alkyl isocyanates, leading to the synthesis of various α-quinolinyl amide compounds in moderate to excellent yields. A plausible mechanism for this transformation is proposed according to the experimental results obtained.
铑（III）催化的 8-甲基喹啉和异氰酸酯的 C(sp)-H 键氨甲酰化反应在温和条件下实现。该方法适用于不同的芳基和烷基异氰酸酯，以中等到优异的收率得到各种α-喹啉基酰胺化合物。根据实验结果提出了这种转化的合理机制。
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