Molnár Levente, Fülesdi Béla, Németh Norbert, Molnár Csilla
Department of Anesthesiology and Intensive Care, Institute of Surgery, University of Debrecen, Hungary.
Department of Operative Techniques and Surgical Research, Institute of Surgery, University of Debrecen, Hungary.
Neurol India. 2018 Mar-Apr;66(2):352-361. doi: 10.4103/0028-3886.227299.
Sepsis is a leading cause of death in medical and surgical intensive care units (ICUs). Disturbance of consciousness of varying severity is an early warning sign of developing sepsis in the majority of cases. Sepsis-associated encephalopathy (SAE) is the most frequent type of encephalopathy in the ICU and is defined as a state of diffuse cerebral dysfunction caused by the inflammatory response of the body to various infections, where the inflammatory process does not affect the central nervous system (CNS) directly and the primary symptom is a disturbed level of consciousness. The aim of this comprehensive review was to collect the latest scientific knowledge regarding the epidemiology, clinical aspects, pathogenesis, diagnosis, and possible prevention strategies related to SAE.
脓毒症是内科和外科重症监护病房（ICU）患者死亡的主要原因。在大多数病例中，不同程度的意识障碍是脓毒症进展的早期预警信号。脓毒症相关性脑病（SAE）是ICU中最常见的脑病类型，其定义为机体对各种感染的炎症反应所导致的弥漫性脑功能障碍状态，其中炎症过程并不直接影响中枢神经系统（CNS），主要症状为意识水平紊乱。本综述的目的是收集有关SAE的流行病学、临床特征、发病机制、诊断及可能预防策略的最新科学知识。
