手性伯胺催化的α-支链醛的不对称氟化反应：试剂控制的对映选择性开关。
Asymmetric Fluorination of α-Branched Aldehydes by Chiral Primary Amine Catalysis: Reagent-Controlled Enantioselectivity Switch.
机构信息
College of Chemistry , Beijing Normal University , Xinjiekouwai Street 19 , Beijing 100875 , China.
Key Laboratory for Molecular Recognition and Function, Institute of Chemistry , The Chinese Academy of Sciences , Beijing 100190 , China.
出版信息
J Org Chem. 2018 Apr 6;83(7):4250-4256. doi: 10.1021/acs.joc.8b00279. Epub 2018 Mar 22.
PMID:29547273
Abstract
Asymmetric fluorination of α-branched aldehydes catalyzed by chiral primary amines under mild conditions has been developed. Both enantiomers could be obtained with good yields (up to 96%) and a high enantioselectivity (up to 90% ee) by a simple swap of the fluorination reagents.
摘要
手性伯胺催化条件温和下α-支链醛的不对称氟化反应被开发出来。通过简单地改变氟化试剂，就能以高收率（高达 96%）和高对映选择性（高达 90%ee）得到两种对映异构体。
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