Allen P I, Goldman M
Clin Phys Physiol Meas. 1987 May;8(2):179-82. doi: 10.1088/0143-0815/8/2/008.
In severely ischaemic lower limbs, the skin response to changing posture from lying to standing is a diagnostic flush. We investigated this observation by measurements of the microcirculation using the non-invasive laser Doppler technique. Eleven patients with ankle: brachial pressure (A:B) ratios less than 0.7 were compared with 13 age-matched controls (A:B ratios greater than 1). In normal subjects, mean horizontal skin blood flow (SBF) was 30.2 +/- 14.9 (+/- SD), significantly greater than mean SBF in the ischaemic group: 12.4 +/- 9.2 (P less than 0.01, Student's t test). Mean SBF fell in the normal group on dependency to 27.5 +/- 16.4 but this change was not significant. Unexpectedly mean SBF rose in the ischaemic limbs to 20.7 +/- 13.8 (P less than 0.05). The pattern of SBF response to change in posture is different in normal and arteriopathic limbs.
在严重缺血的下肢，皮肤对从卧位到站立姿势改变的反应是一种诊断性潮红。我们使用非侵入性激光多普勒技术通过测量微循环来研究这一观察结果。将11名踝肱压（A:B）比值小于0.7的患者与13名年龄匹配的对照组（A:B比值大于1）进行比较。在正常受试者中，平均水平皮肤血流量（SBF）为30.2±14.9（±标准差），显著高于缺血组的平均SBF：12.4±9.2（P<0.01，学生t检验）。正常组在下肢下垂时平均SBF降至27.5±16.4，但这一变化不显著。出乎意料的是，缺血肢体的平均SBF升至20.7±13.8（P<0.05）。正常肢体和动脉病变肢体中SBF对姿势变化的反应模式不同。
