Center for Life Course Health Research, Faculty of Medicine, University of Oulu; Research Unit of Medical Imaging, Physics and Technology, Faculty of Medicine, University of Oulu; Medical Research Center Oulu, Oulu University Hospital and University of Oulu, Oulu, Finland.
Center for Life Course Health Research, Faculty of Medicine, University of Oulu; Medical Research Center Oulu, Oulu University Hospital and University of Oulu, Oulu, Finland.
Spine (Phila Pa 1976). 2018 Sep 15;43(18):E1102-E1108. doi: 10.1097/BRS.0000000000002640.
A population-based birth cohort study.
To investigate the association between gravidity, parity, and vertebral geometry among middle-aged women.
Vertebral size is a recognized determinant of vertebral fracture risk. Yet, only a few lifestyle factors that influence vertebral size are known. Pregnancy is a labile period that may affect the maternal vertebral size or shape. The lumbar lordosis angle is permanently deepened by pregnancy, but it remains unclear whether vertebral shape or size contribute to this deepened angle.
We aimed to investigate whether gravidity and parity were associated with vertebral cross-sectional area (CSA) and height ratio (anterior height to posterior height) among 705 middle-aged women from the Northern Finland Birth Cohort 1966. We measured the corpus of their fourth lumbar vertebra using magnetic resonance imaging of the lumbar spine at the age of 46. Gravidity and parity were elicited using a questionnaire also at the age of 46. Linear regression analysis was used with adjustments for body mass index, vertebral CSA (height ratio models), and vertebral height (CSA models). We also ran a subgroup analysis that did not include nulliparous women, and we compared nulliparous women with grand multiparous women.
The models found no statistically significant associations between the predictors and outcomes. Crude and adjusted results were highly similar, and the subgroup analyses provided analogous results.
Pregnancy, or even multiple pregnancies, do not seem to have long-term effects on vertebral geometry. In order to enhance the prevention of vertebral fractures, future studies should aim to reveal more lifestyle determinants of vertebral size.
基于人群的出生队列研究。
调查中年女性的生育次数和产次与椎体几何形状之间的关系。
椎体大小是椎体骨折风险的公认决定因素。然而，只有少数影响椎体大小的生活方式因素是已知的。妊娠是一个不稳定的时期，可能会影响母体的椎体大小或形状。腰椎前凸角因妊娠而永久性加深，但尚不清楚椎体形状或大小是否对此加深的角度有影响。
我们旨在研究生育次数和产次是否与 705 名来自芬兰北部出生队列 1966 年的中年女性的第四腰椎横截面积（CSA）和高度比（前高与后高比）有关。我们使用腰椎磁共振成像测量了她们的第四腰椎椎体，测量时间为 46 岁。生育次数和产次是通过 46 岁时的问卷调查获得的。我们使用线性回归分析对体重指数、椎体 CSA（高度比模型）和椎体高度（CSA 模型）进行了调整。我们还进行了一个不包括初产妇的亚组分析，并将初产妇与多产妇进行了比较。
模型发现预测因素与结果之间没有统计学上的显著关联。未调整和调整后的结果非常相似，亚组分析也提供了类似的结果。
妊娠，甚至多次妊娠，似乎对椎体几何形状没有长期影响。为了加强对椎体骨折的预防，未来的研究应该旨在揭示更多影响椎体大小的生活方式决定因素。
3。
