Department of Health Sciences Research, Mayo Clinic, Rochester, MN, USA.
Department of Psychology, Mayo Clinic, Rochester, MN, USA.
Neurobiol Aging. 2018 Jun;66:68-74. doi: 10.1016/j.neurobiolaging.2017.11.017. Epub 2018 Feb 19.
Levels of insulin-like growth factor (IGF)-1, IGF-binding protein (IGFBP)-3, and their ratio in the blood may be useful for monitoring those at risk of cognitive and functional decline. However, the association between IGF measures and functional and cognitive outcomes has been mixed, and the associations may vary by sex. The present study investigated the cross-sectional, sex-specific associations between serum measures total IGF-1, IGFBP-3, and the IGF-1/IGFBP-3 ratio, gait speed, and cognition in 1320 cognitively unimpaired participants aged 50-95 years enrolled in the Mayo Clinic Study of Aging. We used multivariable linear regression models to determine the association between IGF measures and gait speed or cognitive test performance by sex. IGF measures were not associated with cognitive or functional performance among men. Among women, higher levels of log total IGF-1 and IGFBP-3 were associated with better performance in attention, visuospatial, and global cognitive domains, independent of the gait speed. These findings suggest that among women, IGF measures are associated with cognition, and these associations are independent of function.
血液中胰岛素样生长因子 (IGF)-1、IGF 结合蛋白 (IGFBP)-3 及其比值水平可能有助于监测有认知和功能下降风险的人群。然而，IGF 指标与功能和认知结果之间的关联并不一致，并且这种关联可能因性别而异。本研究调查了 1320 名认知正常的 50-95 岁参与者的血清总 IGF-1、IGFBP-3 以及 IGF-1/IGFBP-3 比值与步态速度和认知之间的横断面、性别特异性关联，这些参与者均来自 Mayo 诊所老龄化研究。我们使用多变量线性回归模型，根据性别确定 IGF 指标与步态速度或认知测试表现之间的关联。IGF 指标与男性的认知或功能表现无关。而在女性中，较高水平的 log 总 IGF-1 和 IGFBP-3 与注意力、视空间和整体认知领域的表现更好相关，而与步态速度无关。这些发现表明，在女性中，IGF 指标与认知相关，并且这些关联独立于功能。
