Bohnet H G, Kato K
Exp Clin Endocrinol. 1987 Mar;89(1):31-8. doi: 10.1055/s-0029-1210624.
Serum concentrations of 10 hormones in 162 hirsute women were examined. Mean testosterone, dehydroepiandrosterone (DHEA) and DHEA sulfate (DHEA-S) concentrations in these patients were 0.7 ng/ml, 10.0 ng/ml and 3.3 micrograms/ml, respectively; testosterone was elevated in 60.4% of the patients, DHEA was in 52.2% and DHEA-S was in 53.2%. Significant correlations were revealed among all these androgens. In the women who had normal testosterone levels DHEA was elevated in 50.0% and DHEA-S was in 22.2%. Cortisol levels did not show any significant correlation with the androgens examined in this study. Progesterone had a negative correlation with testosterone. Elevations of basal luteinizing hormone (LH) (greater than 20 mIU/ml) were seen in 21.7% of the patients. Stimulation tests using 25 micrograms luteinizing hormone-releasing hormone (LHRH) revealed enormous increase of LH (greater than 100 mIU/ml) in 18.7% of the women. Serum prolactin (PRL) was elevated in 38.3% of the patients; a bolus injection of metoclopramide (MCP) induced hypersecretion of PRL (greater than 160 ng/ml) in 48.0% of the women. These results indicate that the estimations of basal and LHRH- or MCP-induced hormone concentrations in hirsute women give useful clinical information for the understanding of their pathogenesis. More attention should be paid to basal hormone levels before suppression or stimulation tests of adrenal glands and ovary are performed.
检测了162名多毛女性的血清中10种激素的浓度。这些患者的睾酮、脱氢表雄酮（DHEA）和硫酸脱氢表雄酮（DHEA-S）的平均浓度分别为0.7 ng/ml、10.0 ng/ml和3.3μg/ml；60.4%的患者睾酮升高，52.2%的患者DHEA升高，53.2%的患者DHEA-S升高。所有这些雄激素之间均显示出显著相关性。在睾酮水平正常的女性中，50.0%的患者DHEA升高，22.2%的患者DHEA-S升高。皮质醇水平与本研究中检测的雄激素没有任何显著相关性。孕酮与睾酮呈负相关。21.7%的患者基础促黄体生成素（LH）升高（大于20 mIU/ml）。使用25μg促黄体生成素释放激素（LHRH）进行刺激试验发现，18.7%的女性LH大幅升高（大于100 mIU/ml）。38.3%的患者血清催乳素（PRL）升高；静脉注射甲氧氯普胺（MCP）可使48.0%的女性出现PRL分泌过多（大于160 ng/ml）。这些结果表明，对多毛女性基础及LHRH或MCP诱导的激素浓度进行测定，可为了解其发病机制提供有用的临床信息。在对肾上腺和卵巢进行抑制或刺激试验之前，应更加关注基础激素水平。
