Academy of Preventive Medicine, Shandong University, Jinan, China; Shandong Provincial Key Laboratory of Infectious Disease Control and Prevention, Shandong Center for Disease Control and Prevention, Jinan, China.
Shandong Provincial Key Laboratory of Infectious Disease Control and Prevention, Shandong Center for Disease Control and Prevention, Jinan, China.
Vaccine. 2018 Apr 12;36(16):2207-2212. doi: 10.1016/j.vaccine.2018.02.039. Epub 2018 Mar 13.
Hepatitis B breakthrough infection (HBBI) and its risk factors are rarely reported among adults in China. In 2009-2010 in three townships of China, hepatitis B vaccine (HepB) administration and anti-HBs detection after HepB were conducted among the residents aged 18-59 years. HBsAg, anti-HBs and anti-HBc were detected for these vaccinees in 2013. A total of 252 out of 4701 vaccinees turned to be positive for anti-HBc in 2013, but nobody was positive for HBsAg. The HBBI rate was 5.36% (95% CI 4.73, 6.04). The highest rate was found in age-group of 18-29 years (7.33%, 95% CI: 5.31, 9.82). The rate was significantly different by the residential townships (P < 0.001) and by the antibody response to HepB (P = 0.003). Multivariate analysis showed that anti-HBs response to HepB was the independent risk factor of HBBI. The study documents the association between hyporesponse to HepB and HBBI among adults. It also suggests more attention should be given to new HBV infection among young adults.
在中国，成人中乙型肝炎突破性感染（HBBI）及其危险因素的报道很少。2009-2010 年，在中国三个乡镇，对 18-59 岁居民进行了乙型肝炎疫苗（HepB）接种和 HepB 后抗-HBs 检测。2013 年对这些疫苗接种者进行了 HBsAg、抗-HBs 和抗-HBc 检测。2013 年，共有 252 名 4701 名疫苗接种者抗-HBc 检测呈阳性，但没有人 HBsAg 检测呈阳性。HBBI 发生率为 5.36%（95%CI：4.73，6.04）。年龄组为 18-29 岁的发生率最高（7.33%，95%CI：5.31，9.82）。HBBI 发生率在乡镇间差异有统计学意义（P<0.001），与 HepB 抗体反应有关（P=0.003）。多因素分析显示，HepB 抗体反应是 HBBI 的独立危险因素。本研究证实了成人对 HepB 低反应与 HBBI 之间的关系，并提示应更加关注年轻人中的新的乙型肝炎病毒感染。
