Schiattarella Gabriele G, Madonna Rosalinda, Van Linthout Sophie, Thum Thomas, Schulz Rainer, Ferdinandy Peter, Perrino Cinzia
Department of Advanced Biomedical Sciences, Federico II University, Naples, Italy.
Center for Aging Sciences and Translational Medicine - CESI-MeT, Institute of Cardiology, Department of Neurosciences, Imaging and Clinical Sciences, "G. D'Annunzio" University, Chiety, Italy; Center for Cardiovascular Biology and Atherosclerosis Research, Department of Internal Medicine, The University of Texas Health Science Center at Houston, Houston, TX, United States.
Vascul Pharmacol. 2018 Mar 14. doi: 10.1016/j.vph.2018.02.009.
Vascular adaptations to either physiological or pathophysiological conditions commonly require gene expression modifications in the most represented cellular elements of the vessel wall, i.e. endothelial and smooth muscle cells. In addition to transcription factors, a number of mechanisms contribute to the regulation of gene expression in these cells including noncoding RNAs, histone and DNA modifications, collectively indicated as epigenetic modifications. Here, we summarize the state of art regarding the role of epigenetic changes in major vascular diseases, and discuss the potential diagnostic and therapeutic applications of epigenetic modulation in this context.
血管对生理或病理生理条件的适应性通常需要在血管壁中最主要的细胞成分，即内皮细胞和平滑肌细胞中进行基因表达修饰。除转录因子外，许多机制参与调控这些细胞中的基因表达，包括非编码RNA、组蛋白和DNA修饰，这些统称为表观遗传修饰。在此，我们总结了关于表观遗传变化在主要血管疾病中作用的最新研究状况，并讨论了在此背景下表观遗传调控的潜在诊断和治疗应用。
