淋巴结位置是影响甲状腺乳头状癌相关死亡的风险因素。
Lymph node location is a risk factor for papillary thyroid cancer-related death.
机构信息
Endocrinology, Department of Clinical and Experimental Medicine, University of Catania, Garibaldi-Nesima Medical Center, Catania, Italy.
Endocrinology, Department of Clinical and Experimental Medicine, University of Messina, Messina, Italy.
出版信息
J Endocrinol Invest. 2018 Nov;41(11):1349-1353. doi: 10.1007/s40618-018-0865-5. Epub 2018 Mar 16.
PURPOSE
Papillary thyroid cancer (PTC) has good prognosis with a very low chance of mortality. The prognostic role of metastatic lymph node location was judged controversial and more recently (TNM VIII ed.) was considered to have no impact on the prognosis of older patients. The aim of the study was to evaluate the role of metastasized node location on PTC-related mortality.
METHODS
PTC-related mortality was analysed in a consecutive retrospective series of 1653 PTC patients followed at our Thyroid Clinic (mean follow-up 5.9 years).
RESULTS
Sixteen out of 1653 patients (0.96%) died because of PTC. Average age was 68 years at presentation and 74.7 at death. F/M ratio was 1:1. The death rate increased in relation to the lymph node status: 0.2% in N0, 0.3% in N1a and 3.0% in N1b.
CONCLUSIONS
The presence of lymph node metastases in the N1b compartment should be considered as a risk factor for distant metastatic spread and for cancer-related death and included in post-surgery evaluation.
目的
甲状腺乳头状癌（PTC）预后良好，死亡率极低。转移性淋巴结位置的预后作用存在争议，最近（TNM VIII 版）被认为对老年患者的预后没有影响。本研究旨在评估转移淋巴结位置对 PTC 相关死亡率的作用。
方法
对我院甲状腺科连续回顾性系列的 1653 例 PTC 患者（平均随访 5.9 年）进行 PTC 相关死亡率分析。
结果
1653 例患者中有 16 例（0.96%）死于 PTC。发病时的平均年龄为 68 岁，死亡时为 74.7 岁。男女比例为 1:1。死亡率与淋巴结状态有关：N0 为 0.2%，N1a 为 0.3%，N1b 为 3.0%。
结论
N1b 区淋巴结转移的存在应被视为远处转移和癌症相关死亡的危险因素，并应包括在术后评估中。
Zotero 插件