Kowalska Karolina, Habrowska-Górczyńska Dominika E, Neumayer Christoph, Bolliger Michael, Domenig Christoph, Piastowska-Ciesielska Agnieszka W, Huk Ihor, Piechota-Polanczyk Aleksandra
Department of Surgery, Division of Vascular Surgery, Medical University of Vienna, Vienna, Austria.
Laboratory of Cell Cultures and Genomic Analysis, Department of Comparative Endocrinology, Medical University of Lodz, Łódź, Poland.
Acta Biochim Pol. 2018;65(1):111-118. doi: 10.18388/abp.2017_2305. Epub 2018 Mar 15.
This study was undertaken to verify whether simvastatin modulates Cav-1/eNOS expression, and if this modulation is associated with changes in pro- and anti-inflammatory cytokine and Toll-like receptor 4 (TLR4) level in abdominal aortic aneurysm (AAA). It is a 1:2 case-control study of non-statin (n=12) and simvastatin-treated patients (n=24) who underwent open AAA repair. Simvastatin treatment decreased Cav-1 (p<0.05) and increased eNOS expression (p<0.01) in the AAA wall. These changes might be dose dependent. The changes in Cav-1 and eNOS were associated with a trend towards decreased IL-6 and IL-17 concentration (p>0.05) and increased IL-10 concentration (p=0.055); however, TLR4 expression was unaffected, suggesting that simvastatin influences Cav-1 and eNOS in the AAA wall by other mechanisms. Simvastatin may modulate Cav-1 and eNOS expression in the aneurysmal wall, indicating a potentially beneficial role for statins in AAA patients.
本研究旨在验证辛伐他汀是否能调节小窝蛋白-1（Cav-1）/内皮型一氧化氮合酶（eNOS）的表达，以及这种调节是否与腹主动脉瘤（AAA）中促炎和抗炎细胞因子及Toll样受体4（TLR4）水平的变化相关。这是一项1:2的病例对照研究，纳入了接受开放性AAA修复术的未服用他汀类药物的患者（n = 12）和服用辛伐他汀的患者（n = 24）。辛伐他汀治疗可降低AAA壁中的Cav-1（p<0.05）并增加eNOS表达（p<0.01）。这些变化可能具有剂量依赖性。Cav-1和eNOS的变化与IL-6和IL-17浓度降低的趋势（p>0.05）以及IL-10浓度升高（p = 0.055）相关；然而，TLR4表达未受影响，这表明辛伐他汀通过其他机制影响AAA壁中的Cav-1和eNOS。辛伐他汀可能调节动脉瘤壁中的Cav-1和eNOS表达，提示他汀类药物在AAA患者中可能具有潜在的有益作用。
