钯（II）/乙酸碘苯促进了葡糖烯与芳香酸的直接交叉偶联反应。

Pd(II)/PhI(OAc) promoted direct cross coupling of glucals with aromatic acids.

作者信息

Begum Zubeda, Shankar G, Sirisha K, Reddy B V Subba

机构信息

Centre for Semiochemicals, India.

Centre for Nuclear Magnetic Resonance, CSIR-Indian Institute of Chemical Technology, Hyderabad, 500 007, India.

出版信息

Carbohydr Res. 2018 May 22;461:1-3. doi: 10.1016/j.carres.2018.03.002. Epub 2018 Mar 12.

DOI:10.1016/j.carres.2018.03.002

PMID:29549748

Abstract

A highly efficient oxidative C2-aroyloxylation of D-glucal with aromatic carboxylic acids has been achieved for the first time using 5 mol% Pd(OAc) and 1 equiv of PhI(OAc) to produce C2-aroyloxyglycals in good yields. The use of excess of PhI(OAc) (2 equiv) provides C2-acyloxyglycal exclusively.

摘要

首次使用5 mol%的醋酸钯和1当量的醋酸碘苯，实现了D-葡萄糖烯与芳香羧酸的高效氧化C2-芳酰氧基化反应，以良好的产率生成C2-芳酰氧基葡萄糖烯。使用过量的醋酸碘苯（2当量）则仅生成C2-酰氧基葡萄糖烯。