钯（II）催化的 C-H 活化/C-O 形成反应直接实现 2-芳基乙酸的内酯化。
Direct lactonization of 2-arylacetic acids through Pd(II)-catalyzed C-H activation/C-O formation.
机构信息
Beijing National Laboratory for Molecular Sciences (BNLMS), College of Chemistry and Green Chemistry Center, Peking University, Beijing 100871, China.
出版信息
Org Lett. 2013 Feb 1;15(3):690-3. doi: 10.1021/ol303569b. Epub 2013 Jan 15.
PMID:23320461
Abstract
Palladium-catalyzed direct lactonization of 2-arylacetic acids through a reaction sequence that includes C-H activation/C-O formation is reported. This method provides a concise and efficient pathway to synthesize fully functionalized benzofuranone derivatives, which are highly relevant to bioactive natural and synthetic products.
摘要
报道了钯催化的 2-芳基乙酸通过包括 C-H 活化/C-O 形成的反应序列直接内酯化。该方法提供了一种简洁高效的途径来合成全功能化的苯并呋喃酮衍生物，这些衍生物与生物活性的天然和合成产物密切相关。
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