Lojda Z, Kociánová J, Maratka Z
Scand J Gastroenterol Suppl. 1979;54:7-13.
Histochemical examination of aspiration biopsy specimens of the duodenum in 8 healthy volunteers and 23 patients with various gastrointestinal disorders revealed no characteristic abnormality except for a rather frequent absence of the activity of disacharidases especially of lactase. A distinct difference of disacharidase was established between the duodenum and the jejunum in some individuals. A systematic study of different levels of the upper gastrointestinal tract established the fact that the activity of brush border enzymes of enterocytes starts to appear in individually different parts of the duodenum and sometimes even as low as in the jejunum. The distribution of lysosomal enzymes and the activity of dehydrogenases display differences as well. Consequently specimens from different parts of the duodenal and jejunal mucosa are not equivalent and cannot be used alternatively for diagnostic purposes. Biopsies of duodenal mucosa are not adequate for the diagnosis of the malabsorption syndrome.
对8名健康志愿者和23名患有各种胃肠道疾病的患者的十二指肠抽吸活检标本进行组织化学检查发现，除了双糖酶尤其是乳糖酶活性相当频繁地缺乏外，没有特征性异常。在一些个体中，十二指肠和空肠之间双糖酶存在明显差异。对上消化道不同水平的系统研究证实了这样一个事实，即肠细胞刷状缘酶的活性在十二指肠的不同个体部位开始出现，有时甚至低至空肠部位。溶酶体酶的分布和脱氢酶的活性也存在差异。因此，十二指肠和空肠黏膜不同部位的标本并不等同，不能交替用于诊断目的。十二指肠黏膜活检不足以诊断吸收不良综合征。
