哮喘-慢性阻塞性肺疾病重叠（ACO）的流行病学。
Epidemiology of asthma-chronic obstructive pulmonary disease overlap (ACO).
机构信息
Department of Pulmonary Medicine, Graduate School of Medical and Dental Sciences, Kagoshima University, Kagoshima, Japan.
Department of Pulmonary Medicine, Graduate School of Medical and Dental Sciences, Kagoshima University, Kagoshima, Japan.
出版信息
Allergol Int. 2018 Apr;67(2):165-171. doi: 10.1016/j.alit.2018.02.002. Epub 2018 Mar 15.
The term "asthma-COPD overlap" (ACO) has been applied to the condition in which a person has persistent airflow limitation with clinical features of both asthma and COPD. The certain definition and diagnostic criteria for ACO have not yet been established, and ACO prevalence has varied widely in studies: from 0.9% to 11.1% in the general population, from 11.1% to 61.0% in asthma patients, and from 4.2% to 66.0% in COPD patients. Furthermore, the frequency of exacerbations and prognosis in ACO patients have not been clearly demonstrated. Although ACO consists with several subgroups of patients with distinct clinical and pathophysiological features, it would be important to propose a standardized definition of and/or diagnostic criteria for ACO based on biomarkers and objective measures, even if it is tentative. It may lead cohort studies with large population or clinical trials around the world.
“哮喘-慢性阻塞性肺疾病重叠”（ACO）这一术语用于描述具有持续性气流受限、同时具有哮喘和 COPD 临床特征的病症。目前尚未确定 ACO 的明确定义和诊断标准，而且 ACO 的患病率在研究中差异很大：普通人群中为 0.9%至 11.1%，哮喘患者中为 11.1%至 61.0%，COPD 患者中为 4.2%至 66.0%。此外，ACO 患者的发作频率和预后尚不清楚。虽然 ACO 由具有不同临床和病理生理特征的若干亚组患者组成，但基于生物标志物和客观测量提出 ACO 的标准化定义和/或诊断标准非常重要，即使这只是初步的。这可能会导致全世界开展具有较大人群或临床试验的队列研究。
Zotero 插件