Chibby在人鼻咽癌发生发展中的抑癌活性。
Anti-oncogenic activity of Chibby in the development of human nasopharyngeal carcinoma.
作者信息
Cai Cheng-Fu, Liu Li-Man, Shangguan Han-Jing, Liu Cun-Shan, Luo Xian-Yang, Li Yi-Meng
机构信息
Department of Otorhinolaryngology, Head and Neck Surgery, The First Affiliated Hospital, Medical College, Xiamen University, Xiamen, Fujian 361003, P.R. China.
Institute of Stem Cell and Regeneration Medicine, Institutions of Biomedical Science, Fudan University, Shanghai 200031, P.R. China.
出版信息
Oncol Lett. 2018 Apr;15(4):5849-5858. doi: 10.3892/ol.2018.8009. Epub 2018 Feb 9.
The Wnt/β-catenin pathway serves important roles in cancer development. The expression and function of Chibby (Cby), as a direct antagonist of β-catenin, in nasopharyngeal carcinoma (NPC) has not been fully investigated. The present study revealed that the mRNA and protein expression of Cby was significantly lower in NPC tissue than in the adjacent normal tissue. Low expression of Cby was significantly associated with the tumor and the clinical staging. Furthermore, Cby overexpression inhibited the proliferation of human NPC SUNE1 cells and induced cell cycle arrest. In addition, Cby overexpression also significantly enhanced the susceptibility of SUNE1 cells to apoptosis. These results indicated that Cby might serve as an anti-oncogenic gene in the development of NPC and could represent a potential therapeutic target for the human NPC therapy.
Wnt/β-连环蛋白信号通路在癌症发展中发挥重要作用。作为β-连环蛋白的直接拮抗剂，Chibby（Cby）在鼻咽癌（NPC）中的表达及功能尚未得到充分研究。本研究表明，NPC组织中Cby的mRNA和蛋白表达明显低于相邻正常组织。Cby低表达与肿瘤及临床分期显著相关。此外，Cby过表达抑制人NPC SUNE1细胞的增殖并诱导细胞周期停滞。此外，Cby过表达还显著增强了SUNE1细胞对凋亡的敏感性。这些结果表明，Cby可能在NPC发生发展中作为一种抑癌基因，并且可能成为人类NPC治疗的潜在靶点。
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