癌症中的Wnt信号通路。
The Wnt signaling pathway in cancer.
作者信息
Duchartre Yann, Kim Yong-Mi, Kahn Michael
机构信息
Children's Hospital Los Angeles, Department of Pediatrics and Pathology, Division of Hematology, Oncology and Bone Marrow Transplantation, Keck School of Medicine, University of Southern California, Los Angeles, California, United States.
Children's Hospital Los Angeles, Department of Pediatrics and Pathology, Division of Hematology, Oncology and Bone Marrow Transplantation, Keck School of Medicine, University of Southern California, Los Angeles, California, United States.
出版信息
Crit Rev Oncol Hematol. 2016 Mar;99:141-9. doi: 10.1016/j.critrevonc.2015.12.005. Epub 2015 Dec 24.
The Wnt signaling pathway is critically involved in both the development and homeostasis of tissues via regulation of their endogenous stem cells. Aberrant Wnt signaling has been described as a key player in the initiation of and/or maintenance and development of many cancers, via affecting the behavior of Cancer Stem Cells (CSCs). CSCs are considered by most to be responsible for establishment of the tumor and also for disease relapse, as they possess inherent drug-resistance properties. The development of new therapeutic compounds targeting the Wnt signaling pathway promises new hope to eliminate CSCs and achieve cancer eradication. However, a major challenge resides in developing a strategy efficient enough to target the dysregulated Wnt pathway in CSCs, while being safe enough to not damage the normal somatic stem cell population required for tissue homeostasis and repair. Here we review recent therapeutic approaches to target the Wnt pathway and their clinical applications.
Wnt信号通路通过调节组织内源性干细胞，在组织的发育和稳态维持中发挥关键作用。异常的Wnt信号通路被认为是许多癌症发生、维持和发展的关键因素，它通过影响癌症干细胞（CSCs）的行为来实现这一点。大多数人认为，癌症干细胞不仅负责肿瘤的形成，还与疾病复发有关，因为它们具有内在的耐药特性。开发针对Wnt信号通路的新型治疗化合物有望为消除癌症干细胞和实现癌症根治带来新希望。然而，一个主要挑战在于制定一种足够有效的策略，以靶向癌症干细胞中失调的Wnt通路，同时确保安全性，不会损害组织稳态和修复所需的正常体细胞干细胞群体。在此，我们综述了针对Wnt通路的最新治疗方法及其临床应用。
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