Wolny-Rokicka Edyta, Brzeźniakiewicz-Janus Katarzyna, Wydmański Jerzy, Tukiendorf Andrzej, Zembroń-Łacny Agnieszka
1 Department of Radiotherapy, Provincial Multidisciplinary Hospital, Gorzow Wielkopolski, Poland.
2 Faculty of Medicine and Health Sciences, University of Zielona Gora, Zielona Gora, Poland.
J Int Med Res. 2018 May;46(5):1876-1883. doi: 10.1177/0300060517750976. Epub 2018 Mar 19.
Objective To investigate the relationship between changes in inflammatory and coagulatory biomarkers before and after short palliative radiotherapy in patients with advanced stage lung cancer. Methods This prospective observational single-centre study enrolled patients with histologically- or cytologically-confirmed lung cancer who were eligible for palliative radiotherapy. Inflammatory and coagulatory biomarkers including complete blood count, D-dimer and fibrinogen levels were evaluated before and after short hypofractionated radiotherapy. Results Seventy-two patients with advanced stage lung carcinoma were enrolled in this study. Metastases were associated with an increase in white blood cells, neutrophils and mean platelet volume. Increased volume of the primary tumour had a borderline level of correlation with white blood cell and neutrophil counts. After radiotherapy, white blood cells, neutrophils, haemoglobin and lymphocyte counts were decreased. After radiotherapy, the change in fibrinogen and mean platelet volume were borderline significant. Conclusion The levels of inflammatory and coagulatory biomarkers can be used to monitor treatment.
目的 探讨晚期肺癌患者短程姑息性放疗前后炎症和凝血生物标志物的变化关系。方法 本前瞻性单中心观察性研究纳入了经组织学或细胞学确诊且符合姑息性放疗条件的肺癌患者。在短程分割放疗前后评估炎症和凝血生物标志物，包括全血细胞计数、D-二聚体和纤维蛋白原水平。结果 本研究纳入了72例晚期肺癌患者。转移与白细胞、中性粒细胞和平均血小板体积增加有关。原发肿瘤体积增大与白细胞和中性粒细胞计数呈边缘相关性。放疗后，白细胞、中性粒细胞、血红蛋白和淋巴细胞计数下降。放疗后，纤维蛋白原和平均血小板体积的变化具有边缘显著性。结论 炎症和凝血生物标志物水平可用于监测治疗。
