造血干细胞移植后非感染性肺部并发症的当前处理方法。
Current Approach to Non-Infectious Pulmonary Complications of Hematopoietic Stem Cell Transplantation.
机构信息
Department of Hematology, Ankara University School of Medicine, Cebeci Hospital, Ankara, Turkey.
出版信息
Balkan Med J. 2018 Mar 15;35(2):131-140. doi: 10.4274/balkanmedj.2017.1635.
Hematopoietic stem cell transplantation is an established treatment for patients with a wide range of malignant and nonmalignant conditions. Noninfectious pulmonary complications still remain a leading cause of morbidity and mortality in these patients. Treating hematopoietic stem cell transplantation recipients with noninfectious pulmonary complications is still challenging, and the current treatment armamentarium and strategies are not adequate for patients receiving hematopoietic stem cell transplantation. Further trials are needed for a better description of the pathogenesis and the complete diagnostic criteria as well as for the development of effective therapeutic approaches for the management of noninfectious pulmonary complications of the hematopoietic stem cell transplantation. This review outlines the incidence, risk factors, pathogenesis, and clinical spectrum and discusses the current approaches to the management of noninfectious pulmonary complications of Hematopoietic stem cell transplantation.
造血干细胞移植是治疗多种恶性和非恶性疾病患者的一种既定方法。非感染性肺部并发症仍然是这些患者发病率和死亡率的主要原因。治疗造血干细胞移植受者的非感染性肺部并发症仍然具有挑战性，目前的治疗方法和策略并不足以满足接受造血干细胞移植的患者的需求。需要进一步的试验来更好地描述发病机制和完整的诊断标准，并开发有效的治疗方法来管理造血干细胞移植的非感染性肺部并发症。这篇综述概述了造血干细胞移植后非感染性肺部并发症的发生率、危险因素、发病机制和临床谱，并讨论了目前治疗造血干细胞移植后非感染性肺部并发症的方法。
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