利用磁共振成像对梅尼埃病耳和正常听力耳的人类颅神经进行体内形态计量分析
In Vivo Morphometric Analysis of Human Cranial Nerves Using Magnetic Resonance Imaging in Menière's Disease Ears and Normal Hearing Ears.
作者信息
Flatz Wilhelm H, Henneberger Annika, Reiser Maximilian F, Gürkov Robert, Ertl-Wagner Birgit
机构信息
Department of Radiology, University Hospital, LMU Munich;
Department of Otorhinolaryngology - Head and Neck Surgery, SLK-Kliniken Heilbronn GmbH.
出版信息
J Vis Exp. 2018 Feb 21(132):57091. doi: 10.3791/57091.
Analysis of neural structures in Menière's Disease (MD) is of importance, since a loss of such structures has previously been proposed for this patient group but has yet to be confirmed. This protocol describes a method of in vivo evaluation of neural changes especially well suitable for cranial nerve analysis using magnetic resonance imaging (MRI). MD-patients and normal hearing persons were examined in a 3-T MR-scanner using a scan protocol including strongly T2-weighted 3D gradient-echo-sequence (3D-CISS). In the patient group, MD was additionally confirmed using MRI-based assessment of endolymphatic hydrops. Morphometric analysis was performed using a freeware DICOM viewer. Evaluation of cranial nerves included measurements of cross-sectional areas (CSAs) of the nerves at different levels as well as orthogonal diametric measurements.
梅尼埃病（MD）神经结构分析具有重要意义，因为此前曾提出该患者群体存在此类结构缺失，但尚未得到证实。本方案描述了一种体内评估神经变化的方法，该方法特别适用于使用磁共振成像（MRI）进行颅神经分析。MD患者和听力正常者在3-T MR扫描仪中接受检查，扫描方案包括强T2加权3D梯度回波序列（3D-CISS）。在患者组中，还使用基于MRI的内淋巴积水评估来确诊MD。形态计量分析使用免费的DICOM查看器进行。颅神经评估包括测量神经在不同水平的横截面积（CSA）以及正交直径测量。
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