Department of Otorhinolaryngology-Head and Neck Surgery, Integrated Centre for Balance Disorders, Grosshadern Medical Centre, University of Munich, Munich, Germany.
Otol Neurotol. 2012 Aug;33(6):1040-5. doi: 10.1097/MAO.0b013e31825d9a95.
To study the correlation between the degree of endolymphatic hydrops as detected in vivo by magnetic resonance (MR) imaging and the auditory and vestibular function in patients with definite Ménière's disease.
Prospective observational study.
Tertiary referral center for balance disorders.
In this prospective study, 41 patients who fulfilled the criteria for definite unilateral Ménière's disease according to the American Association of Otolaryngology-Head and Neck Surgery and who showed a summating potential-to-action potential ratio of greater than 0.4 on electrocochleography were included. Intratympanic contrast-enhanced 3 Tesla MR imaging of the inner ear was performed using a 3D Inversion Recovery Turbo Spin Echo sequence. The degree of endolymphatic hydrops was graded on a Likert scale (0-3) in the cochlea and by vestibular endolymph space ratio in the vestibulum. The degree of hydrops was then analyzed with respect to its correlation with audiometric hearing levels, interaural amplitude ratios of vestibular evoked myogenic potentials, degree of horizontal semicircular canal paresis on caloric irrigation, and disease duration.
The degree of hearing loss and the disease duration correlated significantly with cochlear hydrops (r = 0.85; r = 0.34). Sacculus dysfunction was significantly correlated with vestibular hydrops (r = -0.47). There was no significant correlation between horizontal semicircular canal paresis and vestibular hydrops.
In patients with clinically and electrocochleographically confirmed definite Ménière's disease, the degree of MR morphological hydrops severity correlates significantly with impairment of hearing function and sacculus function.
研究磁共振（MR）成像体内检测到的内淋巴积水程度与明确梅尼埃病患者的听觉和前庭功能之间的相关性。
前瞻性观察研究。
平衡障碍的三级转诊中心。
在这项前瞻性研究中，纳入了 41 名符合美国耳鼻喉科学-头颈外科学会标准的单侧明确梅尼埃病患者，他们的电 Cochleography 总和潜能与动作潜能比大于 0.4。使用 3D 反转恢复 Turbo Spin Echo 序列对内耳进行经鼓室对比增强 3T MR 成像。在内耳耳蜗和前庭内淋巴空间比上，根据 Likert 量表（0-3）对内淋巴积水程度进行分级。然后分析积水程度与听力水平、前庭诱发肌源性电位的耳间幅度比、冷热刺激时水平半规管麻痹的程度以及疾病持续时间之间的相关性。
听力损失程度和疾病持续时间与耳蜗积水显著相关（r = 0.85；r = 0.34）。球囊功能障碍与前庭积水显著相关（r = -0.47）。水平半规管麻痹与前庭积水无显著相关性。
在临床上和电 Cochleography 证实的明确梅尼埃病患者中，MR 形态学积水严重程度与听力功能和球囊功能障碍显著相关。
