全甲状腺切除术:甲状腺微小乳头状癌的安全且充分的治疗方法。

Total thyroidectomy: safe and adequate treatment for papillary microcarcinoma of the thyroid gland.

作者信息

Uhliarova B, Hajtman A

出版信息

B-ENT. 2016 Aug;12(2):119-124.

DOI:
Abstract

UNLABELLED

Total thyroidectomy: safe and adequate treatment for papillary microcarcinoma of the thyroid gland.

OBJECTIVE

The purpose of this study was to evaluate the incidence of and surgical approach in patients with papillary thyroid microcarcinoma (PTMC; thyroid cancer s10 mm) when these patients underwent surgery for presumed benign thyroid conditions.

MATERIAL AND METHODS

Between January 2006 and December 2013, 1460 adult patients underwent partial or total thyroidectomy for presumed benign thyroid conditions in the Department of Otorhinolaryngology, Head and Neck Surgery, Comenius University, Jessenius Faculty of Medicine, University Hospital in Martin, Slovakia. Of this population, 78 patients with incidental PTMC were further studied.

RESULTS

Incidental papillary microcarcinoma was more frequently detected in patients with multinodular goitre (P = 0.034) or Hashimoto's thyroiditis (P=0.00 13) than in patients with other thyroid diseases. Multifocal and bilateral occurance of PTMC was identified in 26% and 18% of patients, respectively. The initial surgical procedure was -hemithyroidectomy in 23% of patients. All patients initially treated with hemithyroidectomy underwent completion thyroidectomy 10-32 days (median 19 ±7 days) after initial surgery. There were no significant differences in postoperative complications (recurrent laryngeal nerve injury, hypoparathyroidism) between patients with hemithyroidectomy and patients with total thyroidectomy at the first operation (P = 0.647). Completion surgery in patients with hemithyroidectomy was not followed by a significant increase in the incidence of complications (P=0.228).

CONCLUSION

Incidental PTMC is more often detected in patients that undergo surgery for multinodular goitre and Hashimoto's thyroiditis. Total thyroidectomy constitutes a safe and adequate surgical approach in patients with PTMC.

摘要

未标注

全甲状腺切除术:甲状腺微小乳头状癌的安全且充分的治疗方法。

目的

本研究旨在评估甲状腺微小乳头状癌(PTMC;甲状腺癌≤10mm)患者在因疑似良性甲状腺疾病接受手术时的发病率及手术方式。

材料与方法

2006年1月至2013年12月期间,1460例成年患者在斯洛伐克马丁大学医院耶塞纽斯医学院耳鼻喉头颈外科因疑似良性甲状腺疾病接受了部分或全甲状腺切除术。在这一群体中,对78例意外发现PTMC的患者进行了进一步研究。

结果

意外发现的微小乳头状癌在多结节性甲状腺肿患者(P = 0.034)或桥本甲状腺炎患者(P = 0.0013)中比在其他甲状腺疾病患者中更常被检测到。PTMC的多灶性和双侧发生率分别在26%和18%的患者中被发现。23%的患者最初的手术方式为甲状腺叶切除术。所有最初接受甲状腺叶切除术的患者在初次手术后10 - 32天(中位时间19±7天)接受了甲状腺全切术。初次手术时,甲状腺叶切除术患者和全甲状腺切除术患者在术后并发症(喉返神经损伤、甲状旁腺功能减退)方面无显著差异(P = 0.647)。甲状腺叶切除术患者的二次手术并未导致并发症发生率显著增加(P = 0.228)。

结论

意外发现的PTMC在因多结节性甲状腺肿和桥本甲状腺炎接受手术的患者中更常被检测到。全甲状腺切除术是PTMC患者安全且充分的手术方式。

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