Department of Ophthalmology, Research Institute for Convergence of Biomedical Science and Technology, Pusan National University Yangsan Hospital, Yangsan, South Korea.
Department of Ophthalmology, Medical Research Institute, Pusan National University Hospital, Busan, South Korea.
Retina. 2019 Jul;39(7):1361-1369. doi: 10.1097/IAE.0000000000002150.
To investigate the difference in choroidal hyperpermeability (CH) assessed using digital fundus camera (DFC) and scanning laser ophthalmoscope (SLO) and its effect on photodynamic therapy (PDT) outcomes in chronic central serous chorioretinopathy.
Midphase indocyanine green angiography (ICGA) images were acquired using both DFC and SLO in 38 consecutive eyes with chronic central serous chorioretinopathy in this retrospective study. Scanning laser ophthalmoscope-ICGA was taken immediately after DFC-ICGA. Photodynamic therapy was applied to the area of CH associated with subretinal fluid (CH-SRF). The main outcome measures included the areas of CH in the macula and CH-SRF, resolution of SRF, and change in the best-corrected visual acuity.
Areas of CH (5.187 ± 2.625 mm vs. 3.170 ± 1.661 mm, P < 0.001) and CH-SRF (2.315 ± 1.111 mm vs. 1.465 ± 0.709 mm, P < 0.001) were greater in DFC than in SLO. Sixteen eyes underwent DFC ICGA-guided PDT (DFC-PDT group) and 22 underwent SLO ICGA-guided PDT (SLO-PDT group). Subretinal fluid resolution at 12 months was 100.0% and 90.9% in the DFC-PDT and SLO-PDT groups, respectively, without statistical differences. The improvement of best-corrected visual acuity was earlier in the SLO-PDT group than in the DFC-PDT group (3 months, P = 0.002 vs. 6 months, P = 0.003), but the final best-corrected visual acuity showed no difference.
In chronic central serous chorioretinopathy, larger areas of CH and CH-SRF were observed with DFC than with SLO, which caused the ophthalmologists performing ICGA-guided PDT to determine a larger laser spot. This seemed to affect the time of visual recovery, but not the final outcome.
探讨眼底数字相机（DFC）和扫描激光检眼镜（SLO）评估脉络膜高通透性（CH）的差异及其对慢性中心性浆液性脉络膜视网膜病变光动力疗法（PDT）结果的影响。
在这项回顾性研究中，对 38 只连续的慢性中心性浆液性脉络膜视网膜病变眼同时使用 DFC 和 SLO 进行中时吲哚青绿血管造影（ICGA）图像采集。SLO-ICGA 在 DFC-ICGA 后立即进行。将 PDT 应用于与视网膜下液（CH-SRF）相关的 CH 区域。主要观察指标包括黄斑 CH 区和 CH-SRF 区面积、视网膜下液的消退情况以及最佳矫正视力的变化。
DFC 组 CH（5.187±2.625mm 比 3.170±1.661mm，P＜0.001）和 CH-SRF（2.315±1.111mm 比 1.465±0.709mm，P＜0.001）的面积均大于 SLO 组。16 只眼行 DFC ICGA 引导 PDT（DFC-PDT 组），22 只眼行 SLO ICGA 引导 PDT（SLO-PDT 组）。12 个月时，DFC-PDT 组和 SLO-PDT 组视网膜下液的消退率分别为 100.0%和 90.9%，差异无统计学意义。SLO-PDT 组视力矫正的改善早于 DFC-PDT 组（3 个月，P=0.002 比 6 个月，P=0.003），但最终最佳矫正视力无差异。
在慢性中心性浆液性脉络膜视网膜病变中，DFC 观察到的 CH 和 CH-SRF 区面积大于 SLO，这导致进行 ICGA 引导 PDT 的眼科医生确定了更大的激光光斑。这似乎影响了视力恢复的时间，但不影响最终结果。
