Department of Cardiothoracic Surgery, St George's Hospital, London, UK.
Department of Anaesthesia, St George's Hospital, London, UK.
Eur J Cardiothorac Surg. 2018 Oct 1;54(4):696-701. doi: 10.1093/ejcts/ezy110.
Significant proportions of aortic dissections occur at aortic diameters <5.5 cm. By indexing aortic area to height and correlating with absolute aortic diameter, we sought to identify those aneurysm patients with aortic diameters <5.5 cm who do not meet current size thresholds for surgery, yet with corresponding abnormal indexed aortic areas (IAAs) >10 cm2/m, are at increased risk of aortic complications.
IAAs were calculated at 3 aortic locations in 187 aneurysm and 66 dissection patients operated on between 2010 and 2016 at our tertiary aortic centre. Proportions of patients with IAA >10 cm2/m, mean IAAs corresponding to aortic diameters <4.0 cm, 4.0-4.5 cm, 4.5-5.0 cm, 5.0-5.5 cm and >5.5 cm, and mean aortic diameters corresponding to IAAs 10-12 cm2/m, 12-14 cm2/m and >14 cm2/m were determined.
Proportions of patients with abnormal IAAs were similar in both groups. In all, 49.1% of aneurysm patients with aortic diameters 4.5-5.0 cm, and 98.5% with aortic diameters 5.0-5.5 cm had abnormal IAAs. Out of 200 separate aneurysms with IAAs >10 cm2/m between the mid-sinus and mid-ascending aorta, 139 (69.5%) would not warrant surgery according to existing guidelines.
Using the IAA, we identified a significant proportion of patients with thoracic aortic aneurysms who are at increased risk of aortic complications, despite current aortic guidelines not endorsing surgical intervention in this group. Our data suggests the IAA may be useful in preoperative risk evaluation and as a criterion for surgery.
相当比例的主动脉夹层发生在直径<5.5cm 的主动脉处。通过将主动脉面积指数化并与绝对主动脉直径相关联,我们试图确定那些不符合当前手术大小标准但具有相应异常指数化主动脉面积(IAAs)>10cm2/m 的直径<5.5cm 的动脉瘤患者,其主动脉并发症风险增加。
在我们的三级主动脉中心,于 2010 年至 2016 年间对 187 名动脉瘤和 66 名夹层患者进行手术,在 3 个主动脉位置计算 IAAs。确定 IAA>10cm2/m 的患者比例、相应的平均 IAAs 与直径<4.0cm、4.0-4.5cm、4.5-5.0cm、5.0-5.5cm 和>5.5cm 的主动脉直径、以及相应的 IAA 为 10-12cm2/m、12-14cm2/m 和>14cm2/m 的平均主动脉直径。
两组患者中具有异常 IAAs 的患者比例相似。在所有直径 4.5-5.0cm 的动脉瘤患者中,有 49.1%存在异常 IAAs,而在所有直径 5.0-5.5cm 的患者中,有 98.5%存在异常 IAAs。在中窦和升主动脉之间具有>10cm2/m 的 IAAs 的 200 个单独动脉瘤中,根据现有指南,有 139 个(69.5%)不需要手术。
使用 IAA,我们确定了相当比例的胸主动脉瘤患者存在主动脉并发症风险增加,尽管当前的主动脉指南不支持对此类患者进行手术干预。我们的数据表明,IAAs 可能有助于术前风险评估,并作为手术的标准。