Department of Psychiatry, Ludwig Maximilian University, Munich, Germany.
Department of Psychiatry, University Clinic Basel, Basel, Switzerland.
Pharmacopsychiatry. 2019 Mar;52(3):156-159. doi: 10.1055/a-0586-8983. Epub 2018 Mar 19.
Drug reaction with eosinophilia and systemic symptoms (DRESS) is an infrequent, but severe, adverse drug-induced reaction which occurs due to massive T-cell stimulation resulting in cytotoxicity and eosinophil activation and recruitment. The incidence is 0.4 cases per 100, 0000 in the general population; the mortality rate is up to 10%. Therefore, we believe that recognizing this syndrome is of particular importance. The problem we notice is that DRESS is often seen and described in patients receiving rheumatologic or anticonvulsant drugs, but very rarely in psychiatric hospitals, where Clozapine is frequently used, and that is the importance of this paper. DRESS Syndrome must be recognized promptly, and causative drugs withdrawn. Indeed, it has been reported that the earlier the drug withdrawal, the better the prognosis. In this paper, we present three cases of Clozapine-induced DRESS. All cases were recorded in the Multicenter Drug Safety Surveillance Project (AMSP).
药物反应伴嗜酸性粒细胞增多和全身症状（DRESS）是一种罕见但严重的药物诱导的不良反应，由于大量 T 细胞刺激导致细胞毒性和嗜酸性粒细胞活化和募集而发生。在普通人群中，发病率为每 100,0000 人 0.4 例；死亡率高达 10%。因此，我们认为识别这种综合征尤为重要。我们注意到的问题是，DRESS 经常在接受风湿或抗惊厥药物的患者中看到和描述，但在经常使用氯氮平的精神病院很少见，这就是本文的重要性。必须迅速识别 DRESS 综合征，并停用致病药物。事实上，据报道，药物停用越早，预后越好。本文报告了三例氯氮平诱导的 DRESS 病例。所有病例均记录在多中心药物安全监测项目（AMSP）中。
