Richbourg Heather A, Mitchell Colin F, Gillett Ashley N, McNulty Margaret A
Department of Orthopaedic Surgery, University of California San Francisco, San Francisco, CA, USA.
Department of Comparative Biomedical Sciences, Louisiana State University School of Veterinary Medicine, Baton Rouge, LA, USA.
BMC Vet Res. 2018 Mar 20;14(1):105. doi: 10.1186/s12917-018-1423-2.
Tiludronate and clodronate are FDA-approved bisphosphonate drug therapies for navicular disease in horses. Although clinical studies have determined their ability to reduce lameness associated with skeletal disorders in horses, data regarding the effect on bone structure and remodeling is lacking. Additionally, due to off-label use of these drugs in young performance horses, effects on bone in young horses need to be investigated. Therefore, the purpose of this randomized, experimental pilot study was to determine the effect of tiludronate and clodronate on normal bone cells, structure and remodeling after 60 days in clinically normal, young horses. Additionally, the effect of clodronate on bone healing 60 days after an induced defect was investigated.
All horses tolerated surgery well, with no post-surgery lameness and all acquired biopsies being adequate for analyses. Overall, tiludronate and clodronate did not significantly alter any bone structure or remodeling parameters, as evaluated by microCT and dynamic histomorphometry. Tiludronate did not extensively impact bone formation or resorption parameters as evaluated by static histomorphometry. Similarly, clodronate did not affect bone formation or resorption after 60 days. Sixty days post-defect, healing was minimally affected by clodronate.
Tiludronate and clodronate do not appear to significantly impact bone tissue on a structural or cellular level using standard dose and administration schedules.
替鲁膦酸盐和氯膦酸盐是美国食品药品监督管理局（FDA）批准用于治疗马舟骨病的双膦酸盐药物疗法。尽管临床研究已确定它们能够减轻与马骨骼疾病相关的跛行，但关于其对骨结构和重塑影响的数据却很缺乏。此外，由于这些药物在年轻竞技马中的超适应症使用，需要对其对幼马骨骼的影响进行研究。因此，这项随机实验性试点研究的目的是确定替鲁膦酸盐和氯膦酸盐对临床正常的年轻马在60天后正常骨细胞、结构和重塑的影响。此外，还研究了氯膦酸盐对诱导性骨缺损60天后骨愈合的影响。
所有马匹对手术耐受性良好，术后均无跛行，且所有获取的活检样本均足以进行分析。总体而言，通过显微CT和动态组织形态计量学评估，替鲁膦酸盐和氯膦酸盐均未显著改变任何骨结构或重塑参数。通过静态组织形态计量学评估，替鲁膦酸盐并未广泛影响骨形成或吸收参数。同样，氯膦酸盐在60天后也未影响骨形成或吸收。骨缺损60天后，氯膦酸盐对愈合的影响最小。
使用标准剂量和给药方案时，替鲁膦酸盐和氯膦酸盐似乎不会在结构或细胞水平上对骨组织产生显著影响。
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