Coudry Virginie, Thibaud Dominique, Riccio Barbara, Audigié Fabrice, Didierlaurent David, Denoix Jean-Marie
Centre d'Imagerie et de Recherche sur les Affections Locomotrices Equines, Ecole Nationale Vétérinaire d'Alfort, Unité Mixte de Recherche, Institut National de Recherche Agronomique 957, RN 175, 14430 Goustranville, France.
Am J Vet Res. 2007 Mar;68(3):329-37. doi: 10.2460/ajvr.68.3.329.
To evaluate the efficacy of tiludronate for the treatment of horses with signs of pain associated with lesions of the thoracolumbar vertebral column.
29 horses with clinical manifestations of pain associated with lesions of the thoracolumbar vertebral column and abnormal radiographic findings indicative of osteoarthritis of the articular processes-synovial intervertebral joints.
Horses were initially examined in accordance with a standardized protocol, which included radiographic, ultrasonographic, and scintigraphic examinations. Fifteen horses were randomly assigned to receive tiludronate (1 mg/kg, IV, as a slow-rate infusion), and 14 horses received a control substance (day 0). Horses were monitored for the subsequent 120 days. Clinical evaluations were performed on days 60 and 120. Horses that had no evidence of clinical improvement on day 60 were administered tiludronate. Statistical analyses were performed to compare efficacy at day 60, improvement of dorsal flexibility at day 120, and dorsal flexibility before and 60 days after administration of tiludronate.
Horses treated with tiludronate had significant improvement in dorsal flexibility between days 0 and 60, compared with control horses. Clinical improvement in dorsal flexibility was still evident at day 120. The percentage of positive responses was higher in the tiludronate group at 60 days.
Tiludronate had efficacy in the treatment of horses with signs of pain induced by osteoarticular lesions of the thoracolumbar vertebral column, causing a significant improvement in dorsal flexibility. Tiludronate may offer a treatment option for the management of horses with intervertebral lesions and the associated pain.
评估替鲁膦酸盐治疗出现与胸腰椎脊柱病变相关疼痛症状马匹的疗效。
29匹出现与胸腰椎脊柱病变相关疼痛临床表现且X线检查结果异常提示关节突-滑膜椎间关节骨关节炎的马匹。
马匹最初按照标准化方案进行检查，包括X线、超声和闪烁扫描检查。15匹马被随机分配接受替鲁膦酸盐（1毫克/千克，静脉注射，缓慢输注），14匹马接受对照物质（第0天）。对马匹进行随后120天的监测。在第60天和第120天进行临床评估。在第60天无临床改善迹象的马匹给予替鲁膦酸盐。进行统计分析以比较第60天的疗效、第120天背部灵活性的改善情况以及给予替鲁膦酸盐前和给药后60天的背部灵活性。
与对照马匹相比，接受替鲁膦酸盐治疗的马匹在第0天至第60天之间背部灵活性有显著改善。在第120天，背部灵活性的临床改善仍然明显。替鲁膦酸盐组在第60天时阳性反应百分比更高。
替鲁膦酸盐对治疗有胸腰椎脊柱骨关节病变引起疼痛症状的马匹有效，可显著改善背部灵活性。替鲁膦酸盐可能为治疗有椎间病变及相关疼痛的马匹提供一种治疗选择。
