母体糖尿病酮症酸中毒暴露致早产儿发生神经炎症相关脑病。
Neuroinflammation-Related Encephalopathy in an Infant Born Preterm Following Exposure to Maternal Diabetic Ketoacidosis.
机构信息
Alpert Medical School of Brown University, Providence, RI; Department of Neurology, Hasbro Children's Hospital, Providence, RI; Department of Pediatrics, Hasbro Children's Hospital, Providence, RI.
Alpert Medical School of Brown University, Providence, RI; Department of Pediatrics, Women and Infants Hospital of Rhode Island, Providence, RI.
出版信息
J Pediatr. 2018 Jun;197:286-291.e2. doi: 10.1016/j.jpeds.2018.01.052. Epub 2018 Mar 16.
Abstract
A pregnant woman with new-onset type 1 diabetes and ketoacidosis delivered an infant at 28 weeks of gestation who died with multiple organ failure and severe cerebral vasculopathy with extensive hemorrhage, diffuse microgliosis, and edema. This illustrates that antenatal metabolic and inflammatory stressors may be associated with neonatal encephalopathy and cerebral hemorrhage.
摘要
一位新诊断为 1 型糖尿病合并酮症酸中毒的孕妇在妊娠 28 周时分娩，新生儿死于多器官衰竭和严重的脑血管病变，伴有广泛出血、弥漫性小胶质细胞增生和水肿。这表明产前代谢和炎症应激因素可能与新生儿脑病和脑出血有关。
相似文献
1
Neuroinflammation-Related Encephalopathy in an Infant Born Preterm Following Exposure to Maternal Diabetic Ketoacidosis.
J Pediatr. 2018 Jun;197:286-291.e2. doi: 10.1016/j.jpeds.2018.01.052. Epub 2018 Mar 16.
2
Perinatal brain injury in premature infants born to mothers using alcohol in pregnancy. Neonatal Brain Hemorrhage Study Team.
Pediatrics. 1995 Jan;95(1):66-73.
3
Prenatal cocaine exposure and cranial sonographic findings in preterm infants.
J Clin Ultrasound. 2001 Feb;29(2):72-7. doi: 10.1002/1097-0096(200102)29:2<72::AID-JCU1001>3.0.CO;2-F.
4
Effect of late-preterm birth and maternal medical conditions on newborn morbidity risk.
Pediatrics. 2008 Feb;121(2):e223-32. doi: 10.1542/peds.2006-3629.
5
Maternal, placental, and neonatal associations with early germinal matrix/intraventricular hemorrhage in infants born before 32 weeks' gestation.
Am J Perinatol. 1995 Nov;12(6):429-36. doi: 10.1055/s-2007-994514.
6
Leading causes of preterm delivery as risk factors for intraventricular hemorrhage in very preterm infants: results of the EPIPAGE 2 cohort study.
Am J Obstet Gynecol. 2017 May;216(5):518.e1-518.e12. doi: 10.1016/j.ajog.2017.01.002. Epub 2017 Jan 16.
7
Maternal hypertension and neurodevelopmental outcome in very preterm infants.
Arch Dis Child Fetal Neonatal Ed. 1998 Sep;79(2):F88-93. doi: 10.1136/fn.79.2.f88.
8
Effect of obesity on neonatal outcomes in pregnancies with preterm premature rupture of membranes.
Am J Obstet Gynecol. 2016 Feb;214(2):287.e1-287.e5. doi: 10.1016/j.ajog.2015.09.093. Epub 2015 Oct 3.
9
Lung and brain damage in preterm newborns, and their association with gestational age, prematurity subgroup, infection/inflammation and long term outcome.
BJOG. 2005 Mar;112 Suppl 1:4-9. doi: 10.1111/j.1471-0528.2005.00576.x.
10
Maternal and neonatal outcome in triplet, quadruplet and quintuplet gestations following ART: a 11-year study.
Arch Gynecol Obstet. 2013 Oct;288(4):759-67. doi: 10.1007/s00404-013-2796-x. Epub 2013 Mar 30.
本文引用的文献
1
Taurine counteracts the neurotoxic effects of streptozotocin-induced diabetes in rats.
Amino Acids. 2018 Jan;50(1):95-104. doi: 10.1007/s00726-017-2495-1. Epub 2017 Sep 21.
2
β-Hydroxybutyrate in the Brain: One Molecule, Multiple Mechanisms.
Neurochem Res. 2017 Jan;42(1):35-49. doi: 10.1007/s11064-016-2099-2. Epub 2016 Nov 8.
3
Immune and Pancreatic β Cell Interactions in Type 1 Diabetes.
Trends Endocrinol Metab. 2016 Dec;27(12):856-867. doi: 10.1016/j.tem.2016.08.007. Epub 2016 Sep 19.
4
Effect of Associated Autoimmune Diseases on Type 1 Diabetes Mellitus Incidence and Metabolic Control in Children and Adolescents.
Biomed Res Int. 2016;2016:6219730. doi: 10.1155/2016/6219730. Epub 2016 Jul 20.
5
Inflammation in Complicated Pregnancy and Its Outcome.
Am J Perinatol. 2016 Dec;33(14):1337-1356. doi: 10.1055/s-0036-1582397. Epub 2016 May 9.
6
Chronic maternal hyperglycemia induced during mid-pregnancy in rats increases RAGE expression, augments hippocampal excitability, and alters behavior of the offspring.
Neuroscience. 2015 Sep 10;303:241-60. doi: 10.1016/j.neuroscience.2015.06.063. Epub 2015 Jul 4.
7
Developmental programming of brain and behavior by perinatal diet: focus on inflammatory mechanisms.
Dialogues Clin Neurosci. 2014 Sep;16(3):307-20. doi: 10.31887/DCNS.2014.16.3/jbolton.
8
Pathogenesis and prevention of intraventricular hemorrhage.
Clin Perinatol. 2014 Mar;41(1):47-67. doi: 10.1016/j.clp.2013.09.007. Epub 2013 Dec 12.
9
Inpatient management of women with gestational and pregestational diabetes in pregnancy.
Curr Diab Rep. 2014 Feb;14(2):457. doi: 10.1007/s11892-013-0457-x.
10
Maternal immune stimulation during pregnancy shapes the immunological phenotype of offspring.
Brain Behav Immun. 2013 Oct;33:33-45. doi: 10.1016/j.bbi.2013.04.012. Epub 2013 May 3.
Zotero 插件