Programa de Pós-Graduação em Ciências da Saúde, Universidade Federal de Ciências da Saúde de Porto Alegre (UFSCPA), Porto Alegre, Brazil.
Programa de Pós-Graduação em Farmacologia e Terapêutica, Universidade Federal do Rio Grande do Sul, Porto Alegre (UFRGS), Porto Alegre, Brazil.
Amino Acids. 2018 Jan;50(1):95-104. doi: 10.1007/s00726-017-2495-1. Epub 2017 Sep 21.
Diabetes is a chronic metabolic disease associated with oxidative stress, damage to biomolecules such as DNA, and neuroinflammation. Taurine, a sulfur-containing amino acid widespread in the brain, has neuroprotective properties that might prevent tissue injury and DNA damage induced by chronic hyperglycemia. We evaluated the effects of chronic taurine treatment on oxidative stress parameters, DNA damage and inflammatory markers in the frontal cortex, and hippocampus of streptozotocin-induced diabetic rats. Diabetic rats displayed increased levels of reactive oxygen species (ROS) and DNA damage in both areas, evidencing the pro-oxidant effects of diabetes in the brain. Moreover, this condition increased levels of several inflammatory mediators, such as IL-6, IL-12, TNF-γ, and IFN-α, more pronouncedly in the hippocampus. Supporting our hypothesis, taurine treatment reduced ROS, DNA damage, and inflammatory cytokine levels, providing evidence of its beneficial effects against genotoxicity and neuroinflammation associated with diabetes. Our data endorse the necessary clinical trials to evaluate the efficacy and safety of taurine supplementation in the prevention and treatment of neurochemical and metabolic alterations related to diabetes.
糖尿病是一种与氧化应激、生物分子（如 DNA）损伤和神经炎症有关的慢性代谢疾病。牛磺酸是一种广泛存在于大脑中的含硫氨基酸，具有神经保护特性，可能预防慢性高血糖引起的组织损伤和 DNA 损伤。我们评估了慢性牛磺酸治疗对链脲佐菌素诱导的糖尿病大鼠额叶皮质和海马氧化应激参数、DNA 损伤和炎症标志物的影响。糖尿病大鼠在这两个区域的活性氧（ROS）和 DNA 损伤水平均升高，表明糖尿病对大脑具有促氧化作用。此外，这种情况增加了几种炎症介质的水平，如 IL-6、IL-12、TNF-γ 和 IFN-α，在海马中更为明显。支持我们的假设，牛磺酸治疗降低了 ROS、DNA 损伤和炎症细胞因子水平，为其在预防和治疗与糖尿病相关的遗传毒性和神经炎症方面的有益作用提供了证据。我们的数据支持必要的临床试验，以评估牛磺酸补充在预防和治疗与糖尿病相关的神经化学和代谢改变方面的疗效和安全性。
