Zheng Jun, Yu Zhiyuan, Ma Lu, Guo Rui, Lin Sen, You Chao, Li Hao
Department of Neurosurgery, West China Hospital, Sichuan University, Chengdu, Sichuan, China.
Department of Neurosurgery, West China Hospital, Sichuan University, Chengdu, Sichuan, China.
World Neurosurg. 2018 Jun;114:e756-e765. doi: 10.1016/j.wneu.2018.03.077. Epub 2018 Mar 16.
Intracerebral hemorrhage (ICH) is a devastating subtype of stroke. Patients with ICH have poor functional outcomes. The association between blood glucose level and functional outcome in ICH remains unclear. This systematic review and meta-analysis aimed to investigate the association between blood glucose level and functional outcomes in patients with ICH.
Literature was searched systemically in PubMed, EMBASE, Web of Science, and Cochrane Library. Published cohort studies evaluating the association between blood glucose and functional outcome in patients with ICH were included. This meta-analysis was performed using odds ratios (ORs) and 95% confidence intervals (CIs).
A total of 16 studies were included in our meta-analysis. Our data show that hyperglycemia defined by cutoff values was significantly associated with unfavorable functional outcome (OR, 1.80; 95% CI, 1.36-2.39; P < 0.001). Our analysis also suggested a significant association between increased blood glucose levels and functional outcomes (OR, 1.05; 95% CI, 1.03-1.07; P < 0.001).
High blood glucose level is significantly associated with poor functional outcome in ICH. Further studies with larger sample sizes, more time points, and longer follow-up times are necessary to confirm this association.
脑出血（ICH）是一种破坏性的中风亚型。脑出血患者的功能预后较差。脑出血患者血糖水平与功能预后之间的关联仍不明确。本系统评价和荟萃分析旨在研究脑出血患者血糖水平与功能预后之间的关联。
在PubMed、EMBASE、科学网和考克兰图书馆系统检索文献。纳入已发表的评估脑出血患者血糖与功能预后之间关联的队列研究。本荟萃分析采用比值比（OR）和95%置信区间（CI）进行。
我们的荟萃分析共纳入16项研究。我们的数据显示，由临界值定义的高血糖与不良功能预后显著相关（OR，1.80；95%CI，1.36 - 2.39；P < 0.001）。我们的分析还表明血糖水平升高与功能预后之间存在显著关联（OR，1.05；95%CI，1.03 - 1.07；P < 0.001）。
高血糖水平与脑出血患者的不良功能预后显著相关。需要进一步开展样本量更大、时间点更多、随访时间更长的研究来证实这种关联。
