Department of Vascular Biology and Hypertension Program, University of Alabama at Birmingham, Birmingham, AL, USA.
Curr Hypertens Rep. 2018 Mar 19;20(3):23. doi: 10.1007/s11906-018-0819-5.
This review will summarize recent developments in the research on the mineralocorticoid receptor and its impact on obstructive sleep apnea and metabolic syndrome.
Aldosterone excess plays an important role in the association between resistant hypertension and obstructive sleep apnea. The prevalence of obesity is increasing rapidly worldwide and is especially common among patients with obstructive sleep apnea, resistant hypertension, and metabolic syndrome, suggesting probable mechanistic links between these three conditions. Mineralocorticoid receptor expression is increased in obese individuals, which may contribute to the common association between obesity and hyperaldosteronism. Mineralocorticoid receptor blockers reduce the severity of obstructive sleep apnea among resistant hypertension patients. A large body of literature demonstrates a strong association between obesity, hyperaldosteronism, resistant hypertension, and sleep apnea, including specific benefit of treatment with mineralocorticoid receptor blockers for these separate disorders.
本文将总结最近关于醛固酮受体的研究进展及其对阻塞性睡眠呼吸暂停和代谢综合征的影响。
醛固酮过多在抵抗性高血压和阻塞性睡眠呼吸暂停之间的关联中起重要作用。超重肥胖在全世界范围内迅速增加，尤其在阻塞性睡眠呼吸暂停、抵抗性高血压和代谢综合征患者中更为常见，这表明这三种疾病之间可能存在机制联系。肥胖个体中醛固酮受体表达增加，这可能导致肥胖和高醛固酮血症之间的常见关联。醛固酮受体阻滞剂可降低抵抗性高血压患者阻塞性睡眠呼吸暂停的严重程度。大量文献表明肥胖、高醛固酮血症、抵抗性高血压和睡眠呼吸暂停之间存在很强的关联，包括醛固酮受体阻滞剂治疗这些单独疾病的具体益处。
