Puzantian Houry, Townsend Raymond, Bansal Shweta
Hariri School of Nursing, American University of Beirut, Beirut, Lebanon.
Department of Pharmacology and Toxicology, Faculty of Medicine, American University of Beirut, Beirut, Lebanon.
J Clin Hypertens (Greenwich). 2024 Dec;26(12):1384-1390. doi: 10.1111/jch.14898. Epub 2024 Nov 25.
The obesity pandemic, with its associated comorbidities of hypertension and diabetes, constitutes a global public health issue. Importantly, there is an increasing prevalence of aldosterone excess related to obesity and resultant poor health outcomes. Nevertheless, the association between aldosterone and obesity still needs to be clarified. In this review, the authors discuss the role of white adipose tissue in linking obesity, aldosterone excess, and hypertension. The consequences of aldosterone excess in obesity are presented as genomic, non-genomic, and non-epithelial effects. Moreover, the authors emphasize the value of interference with aldosterone pathophysiology (as with mineralocorticoid antagonists) in obesity, thus reducing the adverse clinical impact of aldosterone in myocardial infarction, heart failure, kidney dysfunction, and associated mortality.
肥胖流行及其相关的高血压和糖尿病合并症构成了一个全球公共卫生问题。重要的是，与肥胖相关的醛固酮过量患病率不断上升，并导致不良健康后果。然而，醛固酮与肥胖之间的关联仍需阐明。在这篇综述中，作者讨论了白色脂肪组织在连接肥胖、醛固酮过量和高血压方面的作用。肥胖中醛固酮过量的后果表现为基因组、非基因组和非上皮效应。此外，作者强调了干扰醛固酮病理生理学（如使用盐皮质激素拮抗剂）在肥胖中的价值，从而降低醛固酮在心肌梗死、心力衰竭、肾功能障碍及相关死亡率方面的不良临床影响。
