MacDonald R G, Barbieri E, Feldman R L, Pepine C J
Am J Cardiol. 1987 Jul 1;60(1):50-4. doi: 10.1016/0002-9149(87)90983-0.
Restenosis after successful percutaneous transluminal coronary angioplasty (PTCA) occurs frequently. To better define the restenosis process, a quantitative analysis was performed of coronary angiographic morphologic characteristics at restenosis, before and immediately after PTCA. In 22 patients cine frames showing stenosis at its most severe narrowing were traced and quantitatively analyzed. Immediately after PTCA, stenosis diameter (0.7 +/- 0.3 to 1.9 +/- 0.6 mm, mean +/- standard deviation, p less than 0.05) was increased; percent stenosis (77 +/- 11 to 34 +/- 16%, p less than 0.05), neck index (1.2 +/- 1.4 to 0.5 +/- 0.6, p less than 0.05) and irregularity (9 of 22 patients) were decreased. At follow-up, quantitative coronary morphologic values in most cases were similar to those before PTCA. There were individual changes, which occurred in an unpredictable and highly variable fashion, so that average values were not changed. The eccentricity ratio was not significantly changed by angioplasty or at restenosis. Thus, although successful PTCA results in specific changes in angiographic coronary stenotic morphology, these are reversed by the restenosis process.
经皮腔内冠状动脉成形术（PTCA）成功后再狭窄频繁发生。为了更好地界定再狭窄过程，对PTCA术前、术后即刻以及再狭窄时的冠状动脉造影形态学特征进行了定量分析。对22例患者显示最严重狭窄处狭窄的电影帧进行了描绘和定量分析。PTCA术后即刻，狭窄直径（从0.7±0.3毫米增加至1.9±0.6毫米，均值±标准差，p<0.05）增大；狭窄百分比（从77±11%降至34±16%，p<0.05）、颈部指数（从1.2±1.4降至0.5±0.6，p<0.05）以及不规则性（22例患者中有9例）降低。在随访时，大多数病例的冠状动脉形态学定量值与PTCA术前相似。存在个体变化，这些变化以不可预测且高度可变的方式发生，因此平均值未改变。偏心率在血管成形术时或再狭窄时未发生显著改变。因此，尽管成功的PTCA导致冠状动脉狭窄造影形态学出现特定变化，但这些变化会被再狭窄过程逆转。
