谷胱甘肽 S-转移酶基因是否会改变室内空气污染与哮喘、过敏和肺功能之间的关联？系统评价。
Do Glutathione S-Transferase Genes Modify the Link between Indoor Air Pollution and Asthma, Allergies, and Lung Function? A Systematic Review.
机构信息
Allergy and Lung Health Unit, Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, University of Melbourne, Level 3 207 Bouverie Street, Melbourne, 3010, Australia.
Murdoch Childrens Research Institute, Melbourne, Australia.
出版信息
Curr Allergy Asthma Rep. 2018 Mar 20;18(3):20. doi: 10.1007/s11882-018-0771-0.
PURPOSE OF REVIEW
Glutathione S-transferase (GST) genes are involved in oxidative stress management and may modify the impact of indoor air pollution. We aimed to assess the influence of GST genes on the relationship between indoor air pollution and allergy/lung function.
RECENT FINDINGS
Our systematic review identified 22 eligible studies, with 15 supporting a gene-environment interaction. Carriers of GSTM1/T1 null and GSTP1 val genotypes were more susceptible to indoor air pollution exposures, having a higher risk of asthma and lung function deficits. However, findings differed in terms of risk alleles and specific exposures. High-exposure heterogeneity precluded meta-analysis. We found evidence that respiratory effects of indoor air pollution depend on the individual's GST profile. This may help explain the inconsistent associations found when gene-environment interactions are not considered. Future studies should aim to improve the accuracy of pollution assessment and investigate this finding in different populations.
目的综述
谷胱甘肽 S-转移酶 (GST) 基因参与氧化应激管理，可能改变室内空气污染的影响。我们旨在评估 GST 基因对室内空气污染与过敏/肺功能之间关系的影响。
最新发现
我们的系统综述确定了 22 项符合条件的研究，其中 15 项支持基因-环境相互作用。GSTM1/T1 缺失和 GSTP1 val 基因型的携带者更容易受到室内空气污染暴露的影响，患哮喘和肺功能缺陷的风险更高。然而，在风险等位基因和特定暴露方面，结果存在差异。高暴露异质性排除了荟萃分析。我们有证据表明，室内空气污染的呼吸影响取决于个体的 GST 特征。这可能有助于解释在不考虑基因-环境相互作用时发现的不一致关联。未来的研究应旨在提高污染评估的准确性，并在不同人群中研究这一发现。
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