Wu Chih-Chiang, Ou Chia-Yu, Chang Jen-Chieh, Hsu Te-Yao, Kuo Ho-Chang, Liu Chieh-An, Wang Chih-Lu, Chuang Chia-Ju, Chuang Hau, Liang Hsiu-Mei, Yang Kuender D
Department of Pediatrics, Show Chwan Memorial Hospital, 542 Section 1, Zhongshan Road, Changhua 50008, Taiwan ; Department of Medical Research, Show Chwan Medical System in Chang Bing, 6 Lu-Kung Road, Changhua 50544, Taiwan ; Institute of Clinical Medicine, National Yang-Ming University, 155 Section 2, Linong Street, Taipei 11221, Taiwan.
Department of Obstetrics and Gynecology, Kaohsiung Chang Gung Memorial Hospital, Taiwan and Chang Gung University College of Medicine, 123 Dapi Road, Kaohsiung 83301, Taiwan.
Biomed Res Int. 2014;2014:769452. doi: 10.1155/2014/769452. Epub 2014 Sep 18.
It remains unclear whether the GSTM1 genotype interacts with tobacco smoke exposure (TSE) in asthma development. This study aimed to investigate the interactions among GSTM1 genotype, gender, and prenatal TSE with regard to childhood asthma development. In a longitudinal birth cohort in Taiwan, 756 newborns completed a 6-year follow-up, and 591 children with DNA samples available for GSTM1 genotyping were included in the study, and the interactive influences of gender-GSTM1 genotyping-prenatal TSE on childhood asthma development were analyzed. Among these 591 children, 138 (23.4%) had physician-diagnosed asthma at 6 years of age, and 347 (58.7%) were null-GSTM1. Prenatal TSE significantly increased the prevalence of childhood asthma in null-GSTM1 children relative to those with positive GSTM1. Further analysis showed that prenatal TSE significantly increased the risk of childhood asthma in girls with null-GSTM1. Furthermore, among the children without prenatal TSE, girls with null-GSTM1 had a significantly lower risk of developing childhood asthma and a lower total IgE level at 6 years of age than those with positive GSTM1. This study demonstrates that the GSTM1 null genotype presents a protective effect against asthma development in girls, but the risk of asthma development increases significantly under prenatal TSE.
谷胱甘肽S-转移酶M1（GSTM1）基因型在哮喘发生过程中是否与烟草烟雾暴露（TSE）相互作用仍不清楚。本研究旨在探讨GSTM1基因型、性别和产前TSE在儿童哮喘发生方面的相互作用。在台湾的一个纵向出生队列中，756名新生儿完成了6年的随访，本研究纳入了591名有DNA样本可用于GSTM1基因分型的儿童，并分析了性别-GSTM1基因分型-产前TSE对儿童哮喘发生的交互影响。在这591名儿童中，138名（23.4%）在6岁时被医生诊断为哮喘，347名（58.7%）为GSTM1基因缺失型。相对于GSTM1阳性的儿童，产前TSE显著增加了GSTM1基因缺失型儿童患儿童哮喘的患病率。进一步分析表明，产前TSE显著增加了GSTM1基因缺失型女孩患儿童哮喘的风险。此外，在没有产前TSE的儿童中，GSTM1基因缺失型女孩在6岁时患儿童哮喘的风险显著低于GSTM1阳性的女孩，且总IgE水平也较低。本研究表明，GSTM1基因缺失型对女孩哮喘的发生具有保护作用，但在产前TSE情况下，哮喘发生的风险显著增加。
