Parker D, Graham-Pole J, Malpas J S, Paxton A
Am J Pediatr Hematol Oncol. 1979 Fall;1(3):195-9. doi: 10.1097/00043426-197923000-00001.
A boy with acute lymphoblastic leukemia showed cerebrospinal fluid and blood eosinophilia and basophilia. No cause for the eosinophilia or basophilia was identified, but they preceded the appearance of leukemic lymphoblasts in both CSF and blood. The first appearance of basophils and eosinophils in the CSF was associated with acute symptomatology and responded completely to antileukemic therapy. Though treatment with intrathecal drugs reversed major neurological signs, there was evidence of generalized cerebral cortical atrophy. The possible mechanisms responsible for this unusual cellular reaction include: 1) reaction to antileukemic therapy; 2) immunological reaction to the lymphoblasts; 3) ectopic hormone production; 4) common stem cell origin of lymphoblasts, basophils, and eosinophils. The last explanation seems the most likely.
一名患有急性淋巴细胞白血病的男孩出现脑脊液和血液嗜酸性粒细胞增多及嗜碱性粒细胞增多。未发现嗜酸性粒细胞增多或嗜碱性粒细胞增多的原因，但它们先于脑脊液和血液中白血病原始淋巴细胞的出现。脑脊液中嗜碱性粒细胞和嗜酸性粒细胞的首次出现与急性症状相关，并且对抗白血病治疗完全有反应。尽管鞘内药物治疗逆转了主要的神经系统体征，但有证据表明存在广泛性大脑皮质萎缩。导致这种异常细胞反应的可能机制包括：1）对抗白血病治疗的反应；2）对原始淋巴细胞的免疫反应；3）异位激素产生；4）原始淋巴细胞、嗜碱性粒细胞和嗜酸性粒细胞的共同干细胞起源。最后一种解释似乎最有可能。
