Institute of Organic and Biomolecular Chemistry , Georg-August-University of Göttingen , Tammannstr. 2 , D-37077 Göttingen , Germany.
Institute of Physical Chemistry , Georg-August-University of Göttingen , Tammannstr. 6 , D-37077 Göttingen , Germany.
Org Lett. 2018 Apr 6;20(7):2007-2010. doi: 10.1021/acs.orglett.8b00553. Epub 2018 Mar 20.
A palladium-catalyzed 4-fold domino reaction consisting of two carbopalladation reactions and two C-H activation reactions, followed by the introduction of an acrylate moiety, led to the tetra-substituted helical alkene A2, using the dialkyne A3 as a substrate. The alkene was copolymerized with butyl acrylate by using the reversible addition-fragmentation chain transfer polymerization (RAFT) to give the desired polymeric switch A1.
钯催化的 4 步串联反应，包括两个碳钯化反应和两个 C-H 活化反应，接着引入丙烯酸盐部分，使用二炔 A3 作为底物，得到四取代的螺旋烯烃 A2。该烯烃通过可逆加成-断裂链转移聚合（RAFT）与丙烯酸丁酯共聚，得到所需的聚合物开关 A1。
