Innis R B, Aghajanian G K
Brain Res. 1987 May 12;411(1):139-43. doi: 10.1016/0006-8993(87)90690-1.
Rat substantia nigra was injected with 1 microgram of purified pertussis toxin, a substance which inactivates the inhibitory guanine nucleotide regulatory unit of adenylate cyclase. In comparison to saline-injected animals, the pertussis toxin-treated animals showed almost no inhibition of dopaminergic neurons in response to dopamine applied iontophoretically or the dopamine agonist (-)-apomorphine given intravenously. These results provide evidence that a guanine nucleotide regulatory protein is involved as a transducer in mediating the physiological actions of dopamine autoreceptors.
向大鼠黑质注射1微克纯化的百日咳毒素，该物质可使腺苷酸环化酶的抑制性鸟嘌呤核苷酸调节单位失活。与注射生理盐水的动物相比，经百日咳毒素处理的动物在对经离子电泳施加的多巴胺或静脉注射多巴胺激动剂（-）-阿扑吗啡作出反应时，几乎没有多巴胺能神经元的抑制现象。这些结果证明，鸟嘌呤核苷酸调节蛋白作为一种转导器参与介导多巴胺自身受体的生理作用。
