一种新型希夫碱衍生物的合成、双光子吸收性能及在生物成像中的应用。
A novel Schiff base derivative: Synthesis, two-photon absorption properties and application for bioimaging.
机构信息
Department of Chemistry, Wannan Medical College, Wuhu 241002, People's Republic of China.
Department of Chemistry, Key Laboratory of Functional Inorganic Material Chemistry of Anhui Province, Anhui University, Hefei 230601, PR China.
出版信息
Spectrochim Acta A Mol Biomol Spectrosc. 2018 Jun 5;198:304-308. doi: 10.1016/j.saa.2018.03.039. Epub 2018 Mar 13.
A novel donor-π-acceptor-π-donor type (D-π-A-π-D') Schiff base derivative (L) has been designed and synthesized. The structure of L is confirmed by single-crystal X-ray diffraction analysis as well. The photophysical properties of compound L were comprehensively investigated by using both experimental and theoretical methods. The results indicate that L exhibits large Stokes shift and moderate two-photon action (2PA) cross-section in the near infrared (NIR) region. Furthermore, the confocal microscopy imaging study demonstrates that compound L could penetrate into cells and target the cellular mitochondria compartment. Due to its low cytotoxicity, compound L provides a promising tool for directly lighting up the mitochondria compartment in living HepG2 cells.
一种新型给体-π-受体-π-给体型（D-π-A-π-D'）席夫碱衍生物（L）已被设计和合成。L 的结构也通过单晶 X 射线衍射分析得到证实。通过实验和理论方法综合研究了化合物 L 的光物理性质。结果表明，L 在近红外（NIR）区域表现出大的斯托克斯位移和中等的双光子作用（2PA）截面。此外，共聚焦显微镜成像研究表明，化合物 L 可以穿透细胞并靶向细胞线粒体区室。由于其低细胞毒性，化合物 L 为直接照亮活 HepG2 细胞中的线粒体区室提供了一种有前途的工具。
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