Coremans Laura, de Clerck Frederik
Ghent University Hospital/AZ Sint-Lucas Ziekenhuis, Groene Briel 1, 9000, Ghent, Belgium.
Department of Hepatology and Gastroenterology, AZ Sint-Lucas, Groene Briel 1, 9000, Ghent, Belgium.
BMC Gastroenterol. 2018 Mar 20;18(1):42. doi: 10.1186/s12876-018-0768-0.
Fitz-Hugh-Curtis syndrome or acute perihepatitis is considered a rare complication of pelvic inflammatory disease, mostly associated with chlamydial or gonococcal salpingitis. Peritoneal tuberculosis is a rare site of extra-pulmonary infection caused by Mycobacterium tuberculosis. Infection usually occurs after reactivation of latent tuberculous foci in the peritoneum and more seldom after contiguous spread from tuberculous salpingitis.
We describe a case of a 21-year old female of Somalian origin diagnosed with Fitz-Hugh Curtis syndrome associated with tuberculous salpingitis and peritonitis, presenting with new onset ascites. Acid fast stained smear and polymerase chain reaction for Mycobacterium tuberculosis on ascitic fluid, endocervical culture and tuberculin skin test were all negative. Eventually, the diagnosis was made laparoscopically, showing multiple peritoneal white nodules and perihepatic "violin string" fibrinous strands.
To our knowledge, this is the first case where Fitz-Hugh-Curtis syndrome is associated with both peritoneal and genital tuberculosis and where ascites was the primary clinical finding. Female genital tuberculosis has only rarely been associated with Fitz-Hugh-Curtis syndrome and all cases presented with chronic abdominal pain and/or infertility. Ascites and peritoneal involvement was not present in any case. Moreover, most patients with Fitz-Hugh-Curtis syndrome show no evidence of generalized intra-abdominal infection and only occasionally have concomitant ascites.
菲茨-休-柯蒂斯综合征或急性肝周围炎被认为是盆腔炎的一种罕见并发症,主要与衣原体或淋菌性输卵管炎相关。腹膜结核是由结核分枝杆菌引起的肺外感染的罕见部位。感染通常发生在腹膜潜伏结核病灶重新激活后,很少由结核性输卵管炎直接蔓延所致。
我们描述了一例21岁索马里裔女性病例,该患者被诊断为与结核性输卵管炎和腹膜炎相关的菲茨-休-柯蒂斯综合征,表现为新发腹水。腹水的抗酸染色涂片及结核分枝杆菌聚合酶链反应、宫颈管培养和结核菌素皮肤试验均为阴性。最终,通过腹腔镜检查确诊,发现多个腹膜白色结节和肝周“小提琴弦样”纤维条索。
据我们所知,这是首例菲茨-休-柯蒂斯综合征与腹膜和生殖器结核相关且腹水为主要临床发现的病例。女性生殖器结核很少与菲茨-休-柯蒂斯综合征相关,所有病例均表现为慢性腹痛和/或不孕。既往所有病例均无腹水及腹膜受累情况。此外,大多数菲茨-休-柯蒂斯综合征患者无腹腔内广泛感染的证据,仅有少数伴有腹水。